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Peptide record

TPDB28083

Neurotoxin Toxicity standard
36 amino acids
Basic Information
3D PDB MODEL
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TPDB28083
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 36-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
ADCGWLFHSCESNADCCENWACATTGRFRYLCKYQI
Physicochemical Analysis
C179H258N50O54S6
MPV
C
4166.68
5.38
4
4
13
-1
0.66
-0.247
43.61
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
14355
344.52
15
Residue Composition
number
4
A
2
R
2
N
2
D
6
C
2
E
1
Q
2
G
1
H
1
I
2
L
1
K
0
M
2
F
0
P
2
S
2
T
2
W
2
Y
0
V
Amino Acid Distribution
A: 4 R: 2 N: 2 D: 2 C: 6 E: 2 Q: 1 G: 2 H: 1 I: 1 L: 2 K: 1 M: 0 F: 2 P: 0 S: 2 T: 2 W: 2 Y: 2 V: 0
Chemical Descriptors
36
C179H258N50O54S6
4166.68
5.38
-1
0.66
-0.247
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Blocks calcium channels (Cav). {ECO:0000269|Ref.1}.

Target

voltage-gated calcium channel (Cav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Heteropoda venatoria (Brown huntsman spider) (Aranea venatoria)
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Blocks calcium channels (Cav)..
Omega-sparatoxin-Hv1b (Omega-SPRTX-Hv1b) (Toxin AU5B)
spider
Neurotoxin 10 (Hwtx-1) family, 02 (AU5B) subfamily
Evidence at protein level
Calcium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin Voltage-gated calcium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|Ref.1}.
Additional Detail Fields 7 fields
Calcium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin Voltage-gated calcium channel impairing toxin
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Evidence at protein level
Neurotoxin 10 (Hwtx-1) family, 02 (AU5B) subfamily
Omega-sparatoxin-Hv1b (Omega-SPRTX-Hv1b) (Toxin AU5B)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|Ref.1}.
spider