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Peptide record

TPDB28068

Neurotoxin Toxicity standard
43 amino acids
Basic Information
3D PDB MODEL
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TPDB28068
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 43-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
ACAGLYKKCGKGVNTCCENRPCKCDLAMGNCICKKKFVEFFGG
Physicochemical Analysis
C197H318N56O55S9
QHSW
C
4639.57
8.51
8
3
13
+5
6.64
-0.060
47.67
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
1990
42.89
13
Residue Composition
number
3
A
1
R
3
N
1
D
8
C
2
E
0
Q
6
G
0
H
1
I
2
L
7
K
1
M
3
F
1
P
0
S
1
T
0
W
1
Y
2
V
Amino Acid Distribution
A: 3 R: 1 N: 3 D: 1 C: 8 E: 2 Q: 0 G: 6 H: 0 I: 1 L: 2 K: 7 M: 1 F: 3 P: 1 S: 0 T: 1 W: 0 Y: 1 V: 2
Chemical Descriptors
43
C197H318N56O55S9
4639.57
8.51
+5
6.64
-0.060
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Inhibits high-voltage activated calcium channels. Shifts the voltage-dependence for activation towards hyperpolarized membrane potentials for L- (Cav1), P/Q- (Cav2.1/CACNA1A) and R-type (Cav2.3/CACNA1E) calcium currents. Causes immediate agitation and clockwise gyration, followed by the gradual development of general flaccid paralysis when injected intracerebroventricular into mice at dose levels of 5 ug per mouse. {ECO:0000269|PubMed:17151945}.

Target

voltage-gated calcium channel (Cav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Phoneutria reidyi (Brazilian Amazonian armed spider) (Ctenus reidyi)
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Inhibits high-voltage activated calcium channels. Shifts the voltage-dependence for activation towards hyperpolarized membrane potentials for L- (Cav1), P/Q- (Cav2.1/CACNA1A) and R-type (Cav2.3/CACNA1E) calcium currents.
Omega-ctenitoxin-Pr1a (Omega-CNTX-Pr1a) (Neurotoxin PRTx17C3) (Neurotoxin PRTx3-7) (Tx3-7)
spider
Neurotoxin 02 (plectoxin) family
Evidence at protein level
Amidation Calcium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin Voltage-gated calcium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:16278100, ECO:0000305|PubMed:17151945}.
Additional Detail Fields 7 fields
Amidation Calcium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin Voltage-gated calcium channel impairing toxin
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Evidence at protein level
Neurotoxin 02 (plectoxin) family
Omega-ctenitoxin-Pr1a (Omega-CNTX-Pr1a) (Neurotoxin PRTx17C3) (Neurotoxin PRTx3-7) (Tx3-7)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:16278100, ECO:0000305|PubMed:17151945}.
spider