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Peptide record

TPDB28060

Neurotoxin Toxicity standard
28 amino acids
Basic Information
3D PDB MODEL
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TPDB28060
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 28-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
ACKPKNNLCAITEMAECCSGFCLIYRCS
Physicochemical Analysis
C127H207N35O39S7
DQHWV
C
3072.67
7.62
3
2
10
+1
2.54
0.350
66.43
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
1865
60.70
12
Residue Composition
number
3
A
1
R
2
N
0
D
6
C
2
E
0
Q
1
G
0
H
2
I
2
L
2
K
1
M
1
F
1
P
2
S
1
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 3 R: 1 N: 2 D: 0 C: 6 E: 2 Q: 0 G: 1 H: 0 I: 2 L: 2 K: 2 M: 1 F: 1 P: 1 S: 2 T: 1 W: 0 Y: 1 V: 0
Chemical Descriptors
28
C127H207N35O39S7
3072.67
7.62
+1
2.54
0.350
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Gamma-conotoxins may act on voltage-gated non-specific cation pacemaker channels (HCN). {ECO:0000250}.

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conasprella delessertii (Sozon's cone) (Conus delessertii)
Neurotoxin Ion channel impairing toxin
Gamma-conotoxins may act on voltage-gated non-specific cation pacemaker channels (HCN)..
Gamma-conotoxin-like de7a
cone snail
Conotoxin O1 superfamily
Evidence at protein level
Amidation Direct protein sequencing Disulfide bond Gamma-carboxyglutamic acid Hydroxylation Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom duct.
Additional Detail Fields 7 fields
Amidation Direct protein sequencing Disulfide bond Gamma-carboxyglutamic acid Hydroxylation Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin
Neurotoxin Ion channel impairing toxin
Evidence at protein level
Conotoxin O1 superfamily
Gamma-conotoxin-like de7a
TISSUE SPECIFICITY: Expressed by the venom duct.
cone snail