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Peptide record

TPDB28059

Neurotoxin Toxicity standard
33 amino acids
Basic Information
3D PDB MODEL
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TPDB28059
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 33-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
ACKGLFVTCTPGKDECCPNHVCSSKHKWCKYKI
Physicochemical Analysis
C161H253N45O44S6
RQM
CK
3715.42
8.58
8
2
8
+4
6.73
-0.400
44.24
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
7365
198.23
12
Residue Composition
number
1
A
0
R
1
N
1
D
6
C
1
E
0
Q
2
G
2
H
1
I
1
L
6
K
0
M
1
F
2
P
2
S
2
T
1
W
1
Y
2
V
Amino Acid Distribution
A: 1 R: 0 N: 1 D: 1 C: 6 E: 1 Q: 0 G: 2 H: 2 I: 1 L: 1 K: 6 M: 0 F: 1 P: 2 S: 2 T: 2 W: 1 Y: 1 V: 2
Chemical Descriptors
33
C161H253N45O44S6
3715.42
8.58
+4
6.73
-0.400
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Spider venom neurotoxin that blocks voltage-gated sodium channel Nav1.3/SCN3A in human (IC(50)=80 nM) and rat (IC(50)=160 nM). Partially inhibits human Kv11.1/KCNH2/ERG (25% at 175 uM). {ECO:0000269|Ref.1}.

Target

voltage-gated sodium channel (Nav) voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Cyriopagopus lividus (Cobalt blue tarantula) (Haplopelma lividum)
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin Voltage-gated sodium channel impairing toxin
Spider venom neurotoxin that blocks voltage-gated sodium channel Nav1.3/SCN3A in human (IC(50)=80 nM) and rat (IC(50)=160 nM). Partially inhibits human Kv11.1/KCNH2/ERG (25% at 175 uM)..
Beta/kappa-theraphotoxin-Hlv1a (Beta/kappa-TRTX-Hlv1a) (Beta/kappa-theraphotoxin-Hl2a) (Beta/kappa-TRTX-Hl2a) (Haplotoxin-2)
spider
Neurotoxin 10 (Hwtx-1) family, 11 (haplotoxin-2) subfamily
Evidence at protein level
Amidation Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
Additional Detail Fields 7 fields
Amidation Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Neurotoxin 10 (Hwtx-1) family, 11 (haplotoxin-2) subfamily
Beta/kappa-theraphotoxin-Hlv1a (Beta/kappa-TRTX-Hlv1a) (Beta/kappa-theraphotoxin-Hl2a) (Beta/kappa-TRTX-Hl2a) (Haplotoxin-2)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
spider