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Peptide record

TPDB28054

Neurotoxin Toxicity standard
36 amino acids
Basic Information
3D PDB MODEL
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TPDB28054
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 36-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
ACKDNFAAATCKHVKENKNCGSQKYATNCAKTCGKC
Physicochemical Analysis
C156H256N50O51S6
RILMPW
K
3840.41
8.87
8
2
9
+5
9.51
-0.756
24.72
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
1865
48.56
16
Residue Composition
number
6
A
0
R
4
N
1
D
6
C
1
E
1
Q
2
G
1
H
0
I
0
L
7
K
0
M
1
F
0
P
1
S
3
T
0
W
1
Y
1
V
Amino Acid Distribution
A: 6 R: 0 N: 4 D: 1 C: 6 E: 1 Q: 1 G: 2 H: 1 I: 0 L: 0 K: 7 M: 0 F: 1 P: 0 S: 1 T: 3 W: 0 Y: 1 V: 1
Chemical Descriptors
36
C156H256N50O51S6
3840.41
8.87
+5
9.51
-0.756
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Blocks voltage-gated potassium channels Kv1.2/KCNA2 (IC(50)=140 nM). {ECO:0000269|PubMed:7559645}.

Target

voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Anemonia sulcata (Mediterranean snakelocks sea anemone)
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Blocks voltage-gated potassium channels Kv1.2/KCNA2 (IC(50)=140 nM)..
Kappa-actitoxin-Avd6a (Kappa-AITX-Avd6a) (Kaliseptine) (AsKS)
sea anemone
Sea anemone type 1 potassium channel toxin family, Type 1b subfamily
Evidence at protein level
Direct protein sequencing Disulfide bond Ion channel impairing toxin Nematocyst Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
Additional Detail Fields 6 fields
Direct protein sequencing Disulfide bond Ion channel impairing toxin Nematocyst Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Evidence at protein level
Sea anemone type 1 potassium channel toxin family, Type 1b subfamily
Kappa-actitoxin-Avd6a (Kappa-AITX-Avd6a) (Kaliseptine) (AsKS)
sea anemone