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Peptide record

TPDB28053

Neurotoxin Toxicity standard
37 amino acids
Basic Information
3D PDB MODEL
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TPDB28053
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 37-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
ACKDGFPTATCQHAKLVGNCKNSQKYRANCAKTCGPC
Physicochemical Analysis
C161H262N52O50S6
EIMW
C
3918.53
8.88
7
1
9
+5
7.00
-0.595
31.89
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
1865
47.59
16
Residue Composition
number
5
A
1
R
3
N
1
D
6
C
0
E
2
Q
3
G
1
H
0
I
1
L
5
K
0
M
1
F
2
P
1
S
3
T
0
W
1
Y
1
V
Amino Acid Distribution
A: 5 R: 1 N: 3 D: 1 C: 6 E: 0 Q: 2 G: 3 H: 1 I: 0 L: 1 K: 5 M: 0 F: 1 P: 2 S: 1 T: 3 W: 0 Y: 1 V: 1
Chemical Descriptors
37
C161H262N52O50S6
3918.53
8.88
+5
7.00
-0.595
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Inhibits voltage-gated potassium channels (IC(50)=14.42 nM for rKCNA1/Kv1.1, IC(50)=80.4 nM for rKCNA2/Kv1.2, IC(50)=7.76 nM for rKCNA6/Kv1.6, IC(50)=13.12 nM for hKCNA3/Kv1.3, and IC(50)=49.14 nM for insect Shaker IR). Binds the Shaker IR channels in a voltage-independent manner. {ECO:0000269|PubMed:23466933}.

Target

voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Bunodosoma caissarum (Sea anemone)
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Inhibits voltage-gated potassium channels (IC(50)=14.42 nM for rKCNA1/Kv1.1, IC(50)=80.4 nM for rKCNA2/Kv1.2, IC(50)=7.76 nM for rKCNA6/Kv1.6, IC(50)=13.12 nM for hKCNA3/Kv1.3, and IC(50)=49.14 nM for insect Shaker IR). Binds the Shaker IR channels in a voltage-independent manner..
Kappa-actitoxin-Bcs3b (Kappa-AITX-Bcs3b) (Potassium channel toxin BcsTx2) (BcsTx2)
sea anemone
Sea anemone type 1 potassium channel toxin family, Type 1b subfamily
Evidence at protein level
Direct protein sequencing Disulfide bond Ion channel impairing toxin Nematocyst Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
Additional Detail Fields 6 fields
Direct protein sequencing Disulfide bond Ion channel impairing toxin Nematocyst Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Evidence at protein level
Sea anemone type 1 potassium channel toxin family, Type 1b subfamily
Kappa-actitoxin-Bcs3b (Kappa-AITX-Bcs3b) (Potassium channel toxin BcsTx2) (BcsTx2)
sea anemone