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Peptide record

TPDB28044

Neurotoxin Toxicity standard
38 amino acids
Basic Information
3D PDB MODEL
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TPDB28044
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 38-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
ACIDRFPTGTCKHVKKGGSCKNSQKYRINCAKTCGLCH
Physicochemical Analysis
C173H287N57O50S6
EMW
CK
4157.89
9.58
10
1
8
+7
8.34
-0.595
43.68
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
1865
44.85
15
Residue Composition
number
2
A
2
R
2
N
1
D
6
C
0
E
1
Q
4
G
2
H
2
I
1
L
6
K
0
M
1
F
1
P
2
S
3
T
0
W
1
Y
1
V
Amino Acid Distribution
A: 2 R: 2 N: 2 D: 1 C: 6 E: 0 Q: 1 G: 4 H: 2 I: 2 L: 1 K: 6 M: 0 F: 1 P: 1 S: 2 T: 3 W: 0 Y: 1 V: 1
Chemical Descriptors
38
C173H287N57O50S6
4157.89
9.58
+7
8.34
-0.595
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Inhibits voltage-gated potassium channels (IC(50)=405.0 nM for rKCNA1/Kv1.1, IC(50)=0.03 nM for rKCNA2/Kv1.2, IC(50)=1.31 nM for rKCNA6/Kv1.6, IC(50)=74.11 nM for hKCNA3/Kv1.3, and IC(50)=247.69 nM for insect Shaker IR). Binds the Shaker IR channels in a voltage-independent manner. {ECO:0000269|PubMed:23466933}.

Target

voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Bunodosoma caissarum (Sea anemone)
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Inhibits voltage-gated potassium channels (IC(50)=405.0 nM for rKCNA1/Kv1.1, IC(50)=0.03 nM for rKCNA2/Kv1.2, IC(50)=1.31 nM for rKCNA6/Kv1.6, IC(50)=74.11 nM for hKCNA3/Kv1.3, and IC(50)=247.69 nM for insect Shaker IR). Binds the Shaker IR channels in a voltage-independent manner..
Kappa-actitoxin-Bcs3a (Kappa-AITX-Bcs3a) (Potassium channel toxin BcsTx1) (BcsTx1)
sea anemone
Sea anemone type 1 potassium channel toxin family, Type 1b subfamily
Evidence at protein level
Direct protein sequencing Disulfide bond Ion channel impairing toxin Nematocyst Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
Additional Detail Fields 6 fields
Direct protein sequencing Disulfide bond Ion channel impairing toxin Nematocyst Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Evidence at protein level
Sea anemone type 1 potassium channel toxin family, Type 1b subfamily
Kappa-actitoxin-Bcs3a (Kappa-AITX-Bcs3a) (Potassium channel toxin BcsTx1) (BcsTx1)
sea anemone