Back to search

Peptide record

TPDB28040

Neurotoxin Toxicity standard
23 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB28040
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 23-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
ACGSCRKKCKGPGKCINGRCKCY
Physicochemical Analysis
C98H171N35O27S6
DEQHLMFTWV
C
2464.01
9.61
7
0
3
+7
4.75
-0.696
21.30
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
1865
75.69
9
Residue Composition
number
1
A
2
R
1
N
0
D
6
C
0
E
0
Q
4
G
0
H
1
I
0
L
5
K
0
M
0
F
1
P
1
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 1 R: 2 N: 1 D: 0 C: 6 E: 0 Q: 0 G: 4 H: 0 I: 1 L: 0 K: 5 M: 0 F: 0 P: 1 S: 1 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
23
C98H171N35O27S6
2464.01
9.61
+7
4.75
-0.696
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Reversibly blocks Shaker B potassium channels, with a dissociation constant of 200 nM. {ECO:0000269|PubMed:16309982}.

Target

voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Tityus pachyurus (Colombian scorpion)
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin
Reversibly blocks Shaker B potassium channels, with a dissociation constant of 200 nM..
Potassium channel toxin alpha-KTx 13.3 (Toxin Tpa1)
scorpion
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 13 subfamily
Evidence at protein level
Amidation Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000269|PubMed:16309982}.
Additional Detail Fields 7 fields
Amidation Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin
Evidence at protein level
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 13 subfamily
Potassium channel toxin alpha-KTx 13.3 (Toxin Tpa1)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000269|PubMed:16309982}.
scorpion