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Peptide record

TPDB28038

Neurotoxin Toxicity standard
28 amino acids
Basic Information
3D PDB MODEL
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TPDB28038
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 28-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
ACGPGCSGSCRQKGDRIKCINGSCHCYP
Physicochemical Analysis
C114H186N40O37S6
ELMFTWV
C
2901.34
8.31
5
1
4
+3
4.96
-0.486
31.43
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
1865
64.28
12
Residue Composition
number
1
A
2
R
1
N
1
D
6
C
0
E
1
Q
5
G
1
H
2
I
0
L
2
K
0
M
0
F
2
P
3
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 1 R: 2 N: 1 D: 1 C: 6 E: 0 Q: 1 G: 5 H: 1 I: 2 L: 0 K: 2 M: 0 F: 0 P: 2 S: 3 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
28
C114H186N40O37S6
2901.34
8.31
+3
4.96
-0.486
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Potent and selective inhibitor of Kv1.2/KCNA2 potassium channels. {ECO:0000269|PubMed:11527374}.

Target

voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Orthochirus scrobiculosus (Central Asian scorpion)
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Potent and selective inhibitor of Kv1.2/KCNA2 potassium channels..
Potassium channel toxin alpha-KTx 13.2 (OsK-2) (OsK2)
scorpion
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 13 subfamily
Evidence at protein level
Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland.
Additional Detail Fields 7 fields
Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Evidence at protein level
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 13 subfamily
Potassium channel toxin alpha-KTx 13.2 (OsK-2) (OsK2)
TISSUE SPECIFICITY: Expressed by the venom gland.
scorpion