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Peptide record

TPDB28030

Neurotoxin Toxicity standard
37 amino acids
Basic Information
3D PDB MODEL
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TPDB28030
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 37-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
ACVPVYKECWYPQKPCCEDRVCQCSFGMTNCKCKARL
Physicochemical Analysis
C182H285N51O51S9
HI
C
4292.12
8.09
6
3
11
+3
6.36
-0.300
39.46
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
8980
209.22
15
Residue Composition
number
2
A
2
R
1
N
1
D
8
C
2
E
2
Q
1
G
0
H
0
I
1
L
4
K
1
M
1
F
3
P
1
S
1
T
1
W
2
Y
3
V
Amino Acid Distribution
A: 2 R: 2 N: 1 D: 1 C: 8 E: 2 Q: 2 G: 1 H: 0 I: 0 L: 1 K: 4 M: 1 F: 1 P: 3 S: 1 T: 1 W: 1 Y: 2 V: 3
Chemical Descriptors
37
C182H285N51O51S9
4292.12
8.09
+3
6.36
-0.300
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Antagonist of L-type calcium channels (Cav1/CACNA1). {ECO:0000250}.

Target

voltage-gated calcium channel (Cav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Ctenus ornatus (Brazilian spider) (Oligoctenus ornatus)
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Antagonist of L-type calcium channels (Cav1/CACNA1)..
U10-ctenitoxin-Co1a (U10-CNTX-Co1a) (Neurotoxin Oc FU-5)
spider
Neurotoxin 02 (plectoxin) family
Evidence at protein level
Calcium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin Voltage-gated calcium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|Ref.1}.
Additional Detail Fields 7 fields
Calcium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin Voltage-gated calcium channel impairing toxin
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Evidence at protein level
Neurotoxin 02 (plectoxin) family
U10-ctenitoxin-Co1a (U10-CNTX-Co1a) (Neurotoxin Oc FU-5)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|Ref.1}.
spider