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Peptide record

TPDB28029

Neurotoxin Toxicity standard
30 amino acids
Basic Information
3D PDB MODEL
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TPDB28029
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 30-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
ACVPVYKECWYPQKPCCEDRVCQCSFGMTN
Physicochemical Analysis
C149H223N39O44S7
HIL
C
3489.06
6.09
3
3
9
-0
4.78
-0.313
32.33
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
8855
253.79
13
Residue Composition
number
1
A
1
R
1
N
1
D
6
C
2
E
2
Q
1
G
0
H
0
I
0
L
2
K
1
M
1
F
3
P
1
S
1
T
1
W
2
Y
3
V
Amino Acid Distribution
A: 1 R: 1 N: 1 D: 1 C: 6 E: 2 Q: 2 G: 1 H: 0 I: 0 L: 0 K: 2 M: 1 F: 1 P: 3 S: 1 T: 1 W: 1 Y: 2 V: 3
Chemical Descriptors
30
C149H223N39O44S7
3489.06
6.09
-0
4.78
-0.313
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Antagonist of L-type calcium channels (Cav1/CACNA1). {ECO:0000250}.

Target

voltage-gated calcium channel (Cav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Ctenus ornatus (Brazilian spider) (Oligoctenus ornatus)
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Antagonist of L-type calcium channels (Cav1/CACNA1)..
U10-ctenitoxin-Co1b (U10-CNTX-Co1b) (Neurotoxin Oc M31-11)
spider
Neurotoxin 02 (plectoxin) family
Evidence at protein level
Calcium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin Voltage-gated calcium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|Ref.1}.
Additional Detail Fields 7 fields
Calcium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin Voltage-gated calcium channel impairing toxin
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Evidence at protein level
Neurotoxin 02 (plectoxin) family
U10-ctenitoxin-Co1b (U10-CNTX-Co1b) (Neurotoxin Oc M31-11)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|Ref.1}.
spider