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Peptide record

TPDB28028

Neurotoxin Toxicity standard
23 amino acids
Basic Information
3D PDB MODEL
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TPDB28028
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 23-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
ACVPVYEECGTPKKRCCEERPCK
Physicochemical Analysis
C108H178N32O34S5
NDQHILMFSW
C
2629.10
7.72
5
4
4
+1
12.00
-0.835
29.57
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
1740
66.18
7
Residue Composition
number
1
A
2
R
0
N
0
D
5
C
4
E
0
Q
1
G
0
H
0
I
0
L
3
K
0
M
0
F
3
P
0
S
1
T
0
W
1
Y
2
V
Amino Acid Distribution
A: 1 R: 2 N: 0 D: 0 C: 5 E: 4 Q: 0 G: 1 H: 0 I: 0 L: 0 K: 3 M: 0 F: 0 P: 3 S: 0 T: 1 W: 0 Y: 1 V: 2
Chemical Descriptors
23
C108H178N32O34S5
2629.10
7.72
+1
12.00
-0.835
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Antagonist of L-type calcium channels (Cav1/CACNA1). {ECO:0000250}.

Target

voltage-gated calcium channel (Cav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Ctenus ornatus (Brazilian spider) (Oligoctenus ornatus)
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Antagonist of L-type calcium channels (Cav1/CACNA1)..
U3-ctenitoxin-Co1a (U3-CNTX-Co1a) (Neurotoxin Oc F29-9)
spider
Neurotoxin 02 (plectoxin) family, 01 (Tx3) subfamily
Evidence at protein level
Calcium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin Voltage-gated calcium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|Ref.1}.
Additional Detail Fields 7 fields
Calcium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin Voltage-gated calcium channel impairing toxin
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Evidence at protein level
Neurotoxin 02 (plectoxin) family, 01 (Tx3) subfamily
U3-ctenitoxin-Co1a (U3-CNTX-Co1a) (Neurotoxin Oc F29-9)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|Ref.1}.
spider