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Peptide record

TPDB28026

Neurotoxin Toxicity standard
37 amino acids
Basic Information
3D PDB MODEL
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TPDB28026
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 37-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
ACVGENQQCADWAGPHCCDGYYCTCRYFPKCICRNNN
Physicochemical Analysis
C174H253N53O54S8
LMS
C
4207.73
6.68
4
3
10
-0
3.49
-0.557
26.49
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
10470
248.83
18
Residue Composition
number
3
A
2
R
4
N
2
D
8
C
1
E
2
Q
3
G
1
H
1
I
0
L
1
K
0
M
1
F
2
P
0
S
1
T
1
W
3
Y
1
V
Amino Acid Distribution
A: 3 R: 2 N: 4 D: 2 C: 8 E: 1 Q: 2 G: 3 H: 1 I: 1 L: 0 K: 1 M: 0 F: 1 P: 2 S: 0 T: 1 W: 1 Y: 3 V: 1
Chemical Descriptors
37
C174H253N53O54S8
4207.73
6.68
-0
3.49
-0.557
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Insecticidal neurotoxin that induces an irreversible spastic paralysis when injected into insects. Modifies presynaptic voltage-gated sodium channels (Nav), causing them to open at the normal resting potential of the nerve. This leads to spontaneous release of neurotransmitter and repetitive action potentials in motor neurons. {ECO:0000269|PubMed:2914898}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Agelenopsis aperta (North American funnel-web spider) (Agelenopsis gertschi)
Neurotoxin Presynaptic neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Insecticidal neurotoxin that induces an irreversible spastic paralysis when injected into insects. Modifies presynaptic voltage-gated sodium channels (Nav), causing them to open at the normal resting potential of the nerve.
Mu-agatoxin-Aa1d (Mu-AGTX-Aa1d) (Mu-agatoxin IV) (Mu-Aga IV) (Mu-agatoxin-4)
spider
Neurotoxin 07 (Beta/delta-agtx) family, 03 (aga-4) subfamily, Aga sub-subfamily
Evidence at protein level
Amidation Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Presynaptic neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:2914898}.
Additional Detail Fields 7 fields
Amidation Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Presynaptic neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Presynaptic neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Neurotoxin 07 (Beta/delta-agtx) family, 03 (aga-4) subfamily, Aga sub-subfamily
Mu-agatoxin-Aa1d (Mu-AGTX-Aa1d) (Mu-agatoxin IV) (Mu-Aga IV) (Mu-agatoxin-4)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:2914898}.
spider