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Peptide record

TPDB28022

Neurotoxin Toxicity standard
37 amino acids
Basic Information
3D PDB MODEL
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TPDB28022
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 37-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
ACVGDGQRCASWSGPYCCDGYYCSCRSMPYCRCRNNS
Physicochemical Analysis
C165H245N53O54S9
EHILKFT
C
4123.62
7.84
4
2
9
+2
0.68
-0.559
13.24
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
11960
290.04
20
Residue Composition
number
2
A
4
R
2
N
2
D
8
C
0
E
1
Q
4
G
0
H
0
I
0
L
0
K
1
M
0
F
2
P
5
S
0
T
1
W
4
Y
1
V
Amino Acid Distribution
A: 2 R: 4 N: 2 D: 2 C: 8 E: 0 Q: 1 G: 4 H: 0 I: 0 L: 0 K: 0 M: 1 F: 0 P: 2 S: 5 T: 0 W: 1 Y: 4 V: 1
Chemical Descriptors
37
C165H245N53O54S9
4123.62
7.84
+2
0.68
-0.559
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Insecticidal toxin. Binds to site 4 of insect voltage-gated sodium channel (Nav) and inhibits channel inactivation. In vivo, it lethal to lepidopteran larvae. Has no adverse affects when intracerebroventricularly injected in mice at a dose of 0.2 ug, but causes reversible paralysis of legs when injected intracerebroventricularly in mice at a dose of 2.0 ug. {ECO:0000269|PubMed:10971590, ECO:0000269|PubMed:15683238}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Pireneitega luctuosa (Tangled nest spider) (Paracoelotes luctuosus)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Insecticidal toxin. Binds to site 4 of insect voltage-gated sodium channel (Nav) and inhibits channel inactivation.
Delta-amaurobitoxin-Pl1b (Delta-AMATX-Pl1b) (Delta-palutoxin IT2) (Delta-paluIT2)
spider
Neurotoxin 07 (Beta/delta-agtx) family, 02 (aga-3) subfamily
Evidence at protein level
3D-structure Amidation Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:10971590}.
Additional Detail Fields 7 fields
3D-structure Amidation Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Neurotoxin 07 (Beta/delta-agtx) family, 02 (aga-3) subfamily
Delta-amaurobitoxin-Pl1b (Delta-AMATX-Pl1b) (Delta-palutoxin IT2) (Delta-paluIT2)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:10971590}.
spider