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Peptide record

TPDB27950

Neurotoxin Toxicity standard
37 amino acids
Basic Information
3D PDB MODEL
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TPDB27950
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 37-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
ACATKNQRCASWAGPYCCDGFYCSCRSYPGCMCRPNS
Physicochemical Analysis
C166H247N51O51S9
EHILV
C
4061.64
8.09
4
1
10
+3
-0.52
-0.384
10.81
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
10470
257.78
19
Residue Composition
number
4
A
3
R
2
N
1
D
8
C
0
E
1
Q
3
G
0
H
0
I
0
L
1
K
1
M
1
F
3
P
4
S
1
T
1
W
3
Y
0
V
Amino Acid Distribution
A: 4 R: 3 N: 2 D: 1 C: 8 E: 0 Q: 1 G: 3 H: 0 I: 0 L: 0 K: 1 M: 1 F: 1 P: 3 S: 4 T: 1 W: 1 Y: 3 V: 0
Chemical Descriptors
37
C166H247N51O51S9
4061.64
8.09
+3
-0.52
-0.384
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Binds at site 4 of sodium channels (Nav) and inhibits the fast inactivation of cockroach channels. This toxin is active only on insects (By similarity) Has a potent activity against S.litura larvae. {ECO:0000250, ECO:0000269|PubMed:10971590}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Pireneitega luctuosa (Tangled nest spider) (Paracoelotes luctuosus)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Binds at site 4 of sodium channels (Nav) and inhibits the fast inactivation of cockroach channels. This toxin is active only on insects (By similarity) Has a potent activity against S.litura larvae..
Delta-amaurobitoxin-Pl1d (Delta-AMATX-Pl1d) (Delta-palutoxin IT4) (Delta-paluIT4)
spider
Neurotoxin 07 (Beta/delta-agtx) family, 01 (aga-2) subfamily
Evidence at protein level
Amidation Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000269|PubMed:10971590}.
Additional Detail Fields 7 fields
Amidation Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Neurotoxin 07 (Beta/delta-agtx) family, 01 (aga-2) subfamily
Delta-amaurobitoxin-Pl1d (Delta-AMATX-Pl1d) (Delta-palutoxin IT4) (Delta-paluIT4)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000269|PubMed:10971590}.
spider