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Peptide record

TPDB27932

Neurotoxin Toxicity standard
43 amino acids
Basic Information
3D PDB MODEL
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TPDB27932
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 43-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
AAPCFCPGKPDRGDLWILRGTCPGGYGYTSNCYKWPNICCYPH
Physicochemical Analysis
C214H307N57O57S6
EQMV
CGP
4782.50
8.01
5
2
13
+2
-1.08
-0.400
40.93
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
17335
362.47
15
Residue Composition
number
2
A
2
R
2
N
2
D
6
C
0
E
0
Q
6
G
1
H
2
I
2
L
2
K
0
M
1
F
6
P
1
S
2
T
2
W
4
Y
0
V
Amino Acid Distribution
A: 2 R: 2 N: 2 D: 2 C: 6 E: 0 Q: 0 G: 6 H: 1 I: 2 L: 2 K: 2 M: 0 F: 1 P: 6 S: 1 T: 2 W: 2 Y: 4 V: 0
Chemical Descriptors
43
C214H307N57O57S6
4782.50
8.01
+2
-1.08
-0.400
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Acts as a gating modifier on both Kv and Nav ion channels. Voltage-dependently inhibits voltage-gated potassium channels Kv3 (Kv3.1/KCNC1, Kv3.2/KCNC2 and Kv3.4/KCNC4) (PubMed:16177043, PubMed:9506974). Slows inactivation of the voltage-gated sodium channel Nav1.7/SCN9A (By similarity). Inhibits all Kv3.1, Kv3.2 and Kv3.4 by about 50% when tested at a voltage of +40 mV (PubMed:16177043). May act by binding residues in voltage-sensing domains S3b and S4 of Kv3 (PubMed:16177043). Tests have been done on human Nav1.7/SCN9A and rat SCG neurons that mostly carry Nav1.7 channels (EC(50)=300 nM) (By similarity). This toxin also reduces blood pressure (Ref.1). {ECO:0000250|UniProtKB:P11494, ECO:0000269|PubMed:16177043, ECO:0000269|PubMed:9506974, ECO:0000269|Ref.1}.

Target

voltage-gated sodium channel (Nav) voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Anemonia sulcata (Mediterranean snakelocks sea anemone)
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Acts as a gating modifier on both Kv and Nav ion channels. Voltage-dependently inhibits voltage-gated potassium channels Kv3 (Kv3.1/KCNC1, Kv3.2/KCNC2 and Kv3.4/KCNC4) (PubMed:16177043, PubMed:9506974).
DeltaKappa-actitoxin-Avd4b (DeltaKappa-AITX-Avd4b) (Antihypertensive protein BDS-2) (Blood depressing substance II) (BDS-II)
sea anemone
Sea anemone type 3 (BDS) potassium channel toxin family
Evidence at protein level
Direct protein sequencing Disulfide bond Ion channel impairing toxin Nematocyst Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
Additional Detail Fields 6 fields
Direct protein sequencing Disulfide bond Ion channel impairing toxin Nematocyst Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Evidence at protein level
Sea anemone type 3 (BDS) potassium channel toxin family
DeltaKappa-actitoxin-Avd4b (DeltaKappa-AITX-Avd4b) (Antihypertensive protein BDS-2) (Blood depressing substance II) (BDS-II)
sea anemone