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Peptide record

TPDB27899

Neurotoxin Toxicity standard
35 amino acids
Basic Information
3D PDB MODEL
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TPDB27899
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 35-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
AACLGMFESCDPNNDKCCPNRECNRKHKWCKYKLW
Physicochemical Analysis
C178H272N54O50S7
QITV
C
4192.87
8.31
8
4
9
+3
7.85
-1.037
28.00
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
12865
306.83
12
Residue Composition
number
2
A
2
R
4
N
2
D
6
C
2
E
0
Q
1
G
1
H
0
I
2
L
5
K
1
M
1
F
2
P
1
S
0
T
2
W
1
Y
0
V
Amino Acid Distribution
A: 2 R: 2 N: 4 D: 2 C: 6 E: 2 Q: 0 G: 1 H: 1 I: 0 L: 2 K: 5 M: 1 F: 1 P: 2 S: 1 T: 0 W: 2 Y: 1 V: 0
Chemical Descriptors
35
C178H272N54O50S7
4192.87
8.31
+3
7.85
-1.037
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Blocks Kv4.2/KCND2 voltage-gated potassium channels (IC(50) is 193.0 nM) by shifting the voltage-dependence of channel activation to more depolarized potentials. The toxin is thought to bind to the S3-S4 linker region of the voltage sensor domain. {ECO:0000269|PubMed:15150824, ECO:0000269|PubMed:15208026}.

Target

voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Theraphosa blondi (Goliath birdeating spider)
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Blocks Kv4.2/KCND2 voltage-gated potassium channels (IC(50) is 193.0 nM) by shifting the voltage-dependence of channel activation to more depolarized potentials. The toxin is thought to bind to the S3-S4 linker region of the voltage sensor domain..
Kappa-theraphotoxin-Tb1a (Kappa-TRTX-Tb1a) (Theraphotoxin-1) (TlTx1)
spider
Neurotoxin 10 (Hwtx-1) family, 59 (Tltx) subfamily
Evidence at protein level
Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
Additional Detail Fields 7 fields
Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Evidence at protein level
Neurotoxin 10 (Hwtx-1) family, 59 (Tltx) subfamily
Kappa-theraphotoxin-Tb1a (Kappa-TRTX-Tb1a) (Theraphotoxin-1) (TlTx1)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
spider