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Peptide record

TPDB27893

Neurotoxin Toxicity standard
35 amino acids
Basic Information
3D PDB MODEL
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TPDB27893
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 35-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
AAAISCVGSKECLPKCKAQGCKSGKCMNKKCKCYC
Physicochemical Analysis
C149H259N45O44S9
RDHFTW
CK
3673.51
8.98
8
1
9
+7
7.24
-0.189
42.00
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
1990
54.17
14
Residue Composition
number
4
A
0
R
1
N
0
D
8
C
1
E
1
Q
3
G
0
H
1
I
1
L
8
K
1
M
0
F
1
P
3
S
0
T
0
W
1
Y
1
V
Amino Acid Distribution
A: 4 R: 0 N: 1 D: 0 C: 8 E: 1 Q: 1 G: 3 H: 0 I: 1 L: 1 K: 8 M: 1 F: 0 P: 1 S: 3 T: 0 W: 0 Y: 1 V: 1
Chemical Descriptors
35
C149H259N45O44S9
3673.51
8.98
+7
7.24
-0.189
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Selectively and irreversibly binds (K(d)=2.9 pM) and blocks Kv1.3/KCNA3 potassium channels of human T-lymphocytes. Weakly blocks Kv1.2/KCNA2 (9%). {ECO:0000269|Ref.1}.

Target

voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Vaejovis mexicanus smithi (Mexican scorpion) (Vaejovis smithi)
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Selectively and irreversibly binds (K(d)=2.9 pM) and blocks Kv1.3/KCNA3 potassium channels of human T-lymphocytes. Weakly blocks Kv1.2/KCNA2 (9%)..
Potassium channel toxin alpha-KTx 23.2 (Toxin Vm23) (Toxin alpha-KTx 21.2)
scorpion
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 23 subfamily
Evidence at protein level
Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland.
Additional Detail Fields 7 fields
Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Evidence at protein level
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 23 subfamily
Potassium channel toxin alpha-KTx 23.2 (Toxin Vm23) (Toxin alpha-KTx 21.2)
TISSUE SPECIFICITY: Expressed by the venom gland.
scorpion