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Peptide record

TPDB27874

Neurotoxin Toxicity standard
48 amino acids
Basic Information
3D PDB MODEL
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TPDB27874
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia pep-lab
standard
No
A 48-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and pep-lab, with an available 3D structural model.
Sequence
KKKCIAKDYGRCKWGGTPCCRGRGCICSIMGTNCECKPRLIMEGLGLA
Physicochemical Analysis
C217H368N68O60S10
QHFV
CG
5210.33
8.99
10
3
13
+7
7.83
-0.196
61.04
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
7490
143.75
13
Residue Composition
number
2
A
4
R
1
N
1
D
8
C
2
E
0
Q
8
G
0
H
4
I
3
L
6
K
2
M
0
F
2
P
1
S
2
T
1
W
1
Y
0
V
Amino Acid Distribution
A: 2 R: 4 N: 1 D: 1 C: 8 E: 2 Q: 0 G: 8 H: 0 I: 4 L: 3 K: 6 M: 2 F: 0 P: 2 S: 1 T: 2 W: 1 Y: 1 V: 0
Chemical Descriptors
48
C217H368N68O60S10
5210.33
8.99
+7
7.83
-0.196
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Omega-agatoxins inhibit neuronal voltage-gated calcium channels. This toxin acts by modifying the gating of the high voltage activated P-type Cav2.1/CACNA1A channel. Is a potent blocker in both insect and mammalian central neurons. {ECO:0000269|PubMed:11055992, ECO:0000269|PubMed:11522785, ECO:0000269|PubMed:1311418, ECO:0000269|PubMed:7898748, ECO:0000269|PubMed:8250902, ECO:0000269|PubMed:9120560, ECO:0000269|PubMed:9129813}.

Target

voltage-gated calcium channel (Cav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Agelenopsis aperta (North American funnel-web spider) (Agelenopsis gertschi)
Neurotoxin Presynaptic neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Omega-agatoxins inhibit neuronal voltage-gated calcium channels. This toxin acts by modifying the gating of the high voltage activated P-type Cav2.1/CACNA1A channel.
Omega-agatoxin-Aa4a (Omega-AGTX-Aa4a) (Omega-agatoxin IVA) (Omega-Aga-IVA) (Omega-agatoxin-4A)
spider
Neurotoxin 02 (plectoxin) family, 03 (omega-agtx) subfamily
Evidence at protein level
3D-structure Calcium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Presynaptic neurotoxin Secreted Toxin Voltage-gated calcium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:1311418}.
Additional Detail Fields 7 fields
3D-structure Calcium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Presynaptic neurotoxin Secreted Toxin Voltage-gated calcium channel impairing toxin
Neurotoxin Presynaptic neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Evidence at protein level
Neurotoxin 02 (plectoxin) family, 03 (omega-agtx) subfamily
Omega-agatoxin-Aa4a (Omega-AGTX-Aa4a) (Omega-agatoxin IVA) (Omega-Aga-IVA) (Omega-agatoxin-4A)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:1311418}.
spider