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Peptide record

TPDB27872

Neurotoxin Toxicity standard
48 amino acids
Basic Information
3D PDB MODEL
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TPDB27872
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 pep-lab Peptipedia
standard
No
A 48-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, pep-lab, and Peptipedia, with an available 3D structural model.
Sequence
AACKCDDEGPDIRTAPLTGTVDLGSCNAGWEKCASYYTIIADCCRKKK
Physicochemical Analysis
C216H347N61O72S6
QHMF
AC
5142.86
6.20
7
7
15
-0
10.77
-0.377
59.17
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
8855
172.18
15
Residue Composition
number
6
A
2
R
1
N
5
D
6
C
2
E
0
Q
4
G
0
H
3
I
2
L
5
K
0
M
0
F
2
P
2
S
4
T
1
W
2
Y
1
V
Amino Acid Distribution
A: 6 R: 2 N: 1 D: 5 C: 6 E: 2 Q: 0 G: 4 H: 0 I: 3 L: 2 K: 5 M: 0 F: 0 P: 2 S: 2 T: 4 W: 1 Y: 2 V: 1
Chemical Descriptors
48
C216H347N61O72S6
5142.86
6.20
-0
10.77
-0.377
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Binds specifically to voltage-gated sodium channels (Nav), thereby delaying their inactivation during signal transduction (By similarity). Is highly toxic to crabs (by intrahemocoelic injection) (PubMed:2568126, PubMed:22015268), but without effect upon mice (by intraperitoneal injection) (PubMed:2568126). {ECO:0000250, ECO:0000269|PubMed:22015268, ECO:0000269|PubMed:2568126}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Stichodactyla helianthus (Sun anemone) (Stoichactis helianthus)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Binds specifically to voltage-gated sodium channels (Nav), thereby delaying their inactivation during signal transduction (By similarity). Is highly toxic to crabs (by intrahemocoelic injection) (PubMed:2568126, PubMed:22015268), but without effect upon mice (by intraperitoneal injection) (PubMed:2568126)..
Delta-stichotoxin-She1a (Delta-SHTX-She1a) (Neurotoxin I) (Neurotoxin Sh I) (ShI) (SHNA) (Sh1) (Toxin SHP-I)
sea anemone
Sea anemone sodium channel inhibitory toxin family, Type II subfamily
Evidence at protein level
3D-structure Direct protein sequencing Disulfide bond Ion channel impairing toxin Nematocyst Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Additional Detail Fields 6 fields
3D-structure Direct protein sequencing Disulfide bond Ion channel impairing toxin Nematocyst Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Sea anemone sodium channel inhibitory toxin family, Type II subfamily
Delta-stichotoxin-She1a (Delta-SHTX-She1a) (Neurotoxin I) (Neurotoxin Sh I) (ShI) (SHNA) (Sh1) (Toxin SHP-I)
sea anemone