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Peptide record

TPDB27871

Neurotoxin Toxicity standard
47 amino acids
Basic Information
3D PDB MODEL
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TPDB27871
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 pep-lab Peptipedia
standard
No
A 47-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, pep-lab, and Peptipedia, with an available 3D structural model.
Sequence
GVPCRCDSDGPSVHGNTLSGTVWVGSCASGWHKCNDEYNIAYECCKE
Physicochemical Analysis
C210H313N61O72S6
QMF
CG
5036.52
4.73
5
6
12
-3
9.66
-0.466
45.53
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
14355
285.02
18
Residue Composition
number
2
A
1
R
3
N
3
D
6
C
3
E
0
Q
6
G
2
H
1
I
1
L
2
K
0
M
0
F
2
P
5
S
2
T
2
W
2
Y
4
V
Amino Acid Distribution
A: 2 R: 1 N: 3 D: 3 C: 6 E: 3 Q: 0 G: 6 H: 2 I: 1 L: 1 K: 2 M: 0 F: 0 P: 2 S: 5 T: 2 W: 2 Y: 2 V: 4
Chemical Descriptors
47
C210H313N61O72S6
5036.52
4.73
-3
9.66
-0.466
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Slows down the inactivation process of TTX-sensitive voltage-gated sodium channels (Nav) (PubMed:16814340). Has a strong crab-paralyzing activity (PubMed:16814340). The minimum lethal dose against crabs is 7.9 mg/kg (Ref.1). {ECO:0000269|PubMed:16814340, ECO:0000269|Ref.1}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Condylactis gigantea (Giant Caribbean anemone) (Condylactis passiflora)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Slows down the inactivation process of TTX-sensitive voltage-gated sodium channels (Nav) (PubMed:16814340). Has a strong crab-paralyzing activity (PubMed:16814340).
Delta-actitoxin-Cgg1a (Delta-AITX-Cgg1a) (Toxin CgNa) (Toxin Cp-2) (CpII) (Toxin Cp II)
sea anemone
Sea anemone sodium channel inhibitory toxin family, Type I subfamily
Evidence at protein level
3D-structure Direct protein sequencing Disulfide bond Hydroxylation Ion channel impairing toxin Nematocyst Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Additional Detail Fields 6 fields
3D-structure Direct protein sequencing Disulfide bond Hydroxylation Ion channel impairing toxin Nematocyst Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Sea anemone sodium channel inhibitory toxin family, Type I subfamily
Delta-actitoxin-Cgg1a (Delta-AITX-Cgg1a) (Toxin CgNa) (Toxin Cp-2) (CpII) (Toxin Cp II)
sea anemone