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Peptide record

TPDB27869

Neurotoxin Toxicity standard
46 amino acids
Basic Information
3D PDB MODEL
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TPDB27869
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 pep-lab Peptipedia
standard
No
A 46-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, pep-lab, and Peptipedia, with an available 3D structural model.
Sequence
GPSFCKADEKPCEYHADCCNCCLSGICAPSTNWILPGCSTSSFFKI
Physicochemical Analysis
C212H318N54O66S8
RQMV
C
4935.66
5.37
4
4
13
-1
3.50
0.065
48.91
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
7490
151.75
19
Residue Composition
number
3
A
0
R
2
N
2
D
8
C
2
E
0
Q
3
G
1
H
3
I
2
L
3
K
0
M
3
F
4
P
6
S
2
T
1
W
1
Y
0
V
Amino Acid Distribution
A: 3 R: 0 N: 2 D: 2 C: 8 E: 2 Q: 0 G: 3 H: 1 I: 3 L: 2 K: 3 M: 0 F: 3 P: 4 S: 6 T: 2 W: 1 Y: 1 V: 0
Chemical Descriptors
46
C212H318N54O66S8
4935.66
5.37
-1
3.50
0.065
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Iota-conotoxins bind to voltage-gated sodium channels and act as agonists by shifting the voltage-dependence of activation to more hyperpolarized levels. This toxin acts on Nav1.6/SCN8A > Nav1.2/SCN2A > Nav1.7/SCN9A sodium channels. Produces general excitatory symptoms upon intracorporeal injection and repetitive action potentials in the frog cutaneous pectoris muscle. Natural peptide (with D-Phe) is active on nerve, but not on muscle. Synthetic peptide (with L-Phe) is not active on both nerve and muscle. {ECO:0000269|PubMed:17696362, ECO:0000269|PubMed:18486102}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus radiatus (Rayed cone)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Iota-conotoxins bind to voltage-gated sodium channels and act as agonists by shifting the voltage-dependence of activation to more hyperpolarized levels. This toxin acts on Nav1.6/SCN8A > Nav1.2/SCN2A > Nav1.7/SCN9A sodium channels.
Iota-conotoxin RXIA (R11.6) (r11a)
cone snail
Conotoxin I1 superfamily
Evidence at protein level
3D-structure D-amino acid Direct protein sequencing Disulfide bond Hydroxylation Ion channel impairing toxin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom duct.
Additional Detail Fields 7 fields
3D-structure D-amino acid Direct protein sequencing Disulfide bond Hydroxylation Ion channel impairing toxin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Conotoxin I1 superfamily
Iota-conotoxin RXIA (R11.6) (r11a)
TISSUE SPECIFICITY: Expressed by the venom duct.
cone snail