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Peptide record

TPDB27868

Neurotoxin Toxicity standard
46 amino acids
Basic Information
3D PDB MODEL
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TPDB27868
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 pep-lab Peptipedia
standard
No
A 46-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, pep-lab, and Peptipedia, with an available 3D structural model.
Sequence
GAACLCKSDGPNTRGNSMSGTIWVFGCPSGWNNCEGRAIIGYCCKQ
Physicochemical Analysis
C201H311N61O63S7
H
G
4814.47
8.02
4
2
13
+2
1.52
-0.191
46.74
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
12865
267.22
18
Residue Composition
number
3
A
2
R
4
N
1
D
6
C
1
E
1
Q
8
G
0
H
3
I
1
L
2
K
1
M
1
F
2
P
4
S
2
T
2
W
1
Y
1
V
Amino Acid Distribution
A: 3 R: 2 N: 4 D: 1 C: 6 E: 1 Q: 1 G: 8 H: 0 I: 3 L: 1 K: 2 M: 1 F: 1 P: 2 S: 4 T: 2 W: 2 Y: 1 V: 1
Chemical Descriptors
46
C201H311N61O63S7
4814.47
8.02
+2
1.52
-0.191
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Binds specifically to voltage-gated sodium channels (Nav) and delays their inactivation during signal transduction (when tested on the soma membrane of a crustacean neuron). Has also been observed to affect the activation of the sodium current. {ECO:0000269|PubMed:2409523}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Anemonia sulcata (Mediterranean snakelocks sea anemone)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Binds specifically to voltage-gated sodium channels (Nav) and delays their inactivation during signal transduction (when tested on the soma membrane of a crustacean neuron). Has also been observed to affect the activation of the sodium current..
Delta-actitoxin-Avd1a (Delta-AITX-Avd1a) (As1) (Delta-actitoxin-Avd1b) (Delta-AITX-Avd1b) (Toxin ATX-I) (ATX I) (Toxin-1)
sea anemone
Sea anemone sodium channel inhibitory toxin family, Type I subfamily
Evidence at protein level
3D-structure Direct protein sequencing Disulfide bond Ion channel impairing toxin Nematocyst Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Additional Detail Fields 6 fields
3D-structure Direct protein sequencing Disulfide bond Ion channel impairing toxin Nematocyst Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Sea anemone sodium channel inhibitory toxin family, Type I subfamily
Delta-actitoxin-Avd1a (Delta-AITX-Avd1a) (As1) (Delta-actitoxin-Avd1b) (Delta-AITX-Avd1b) (Toxin ATX-I) (ATX I) (Toxin-1)
sea anemone