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Peptide record

TPDB27866

Neurotoxin Toxicity standard
45 amino acids
Basic Information
3D PDB MODEL
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TPDB27866
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia pep-lab
standard
No
A 45-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and pep-lab, with an available 3D structural model.
Sequence
LLACLFGNGRCSSNRDCCELTPVCKRGSCVSSGPGLVGGILGGIL
Physicochemical Analysis
C187H317N57O58S6
QHMWY
G
4484.28
8.02
4
2
14
+2
2.22
0.553
99.56
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
375
8.36
14
Residue Composition
number
1
A
3
R
2
N
1
D
6
C
1
E
0
Q
9
G
0
H
2
I
7
L
1
K
0
M
1
F
2
P
5
S
1
T
0
W
0
Y
3
V
Amino Acid Distribution
A: 1 R: 3 N: 2 D: 1 C: 6 E: 1 Q: 0 G: 9 H: 0 I: 2 L: 7 K: 1 M: 0 F: 1 P: 2 S: 5 T: 1 W: 0 Y: 0 V: 3
Chemical Descriptors
45
C187H317N57O58S6
4484.28
8.02
+2
2.22
0.553
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Potent inhibitor of insect (bee brain), but not mammalian (rat trigeminal neurons), voltage-gated calcium channels (Cav). In vivo, injection into lone star ticks (Amblyomma americanum) induces curling of all eight legs into closed loops, followed by death. {ECO:0000269|PubMed:16330063}.

Target

voltage-gated calcium channel (Cav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Hadronyche versuta (Blue mountains funnel-web spider) (Atrax versutus)
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Potent inhibitor of insect (bee brain), but not mammalian (rat trigeminal neurons), voltage-gated calcium channels (Cav). In vivo, injection into lone star ticks (Amblyomma americanum) induces curling of all eight legs into closed loops, followed by death..
Omega-hexatoxin-Hv2a (Omega-HXTX-Hv2a) (Omega-atracotoxin-Hv2a) (AcTx-Hv2) (Omega-AcTx-Hv2a)
spider
Neurotoxin 15 family, 02 (omega-actx) subfamily
Evidence at protein level
3D-structure Calcium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin Voltage-gated calcium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:11522785}.
Additional Detail Fields 7 fields
3D-structure Calcium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin Voltage-gated calcium channel impairing toxin
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Evidence at protein level
Neurotoxin 15 family, 02 (omega-actx) subfamily
Omega-hexatoxin-Hv2a (Omega-HXTX-Hv2a) (Omega-atracotoxin-Hv2a) (AcTx-Hv2) (Omega-AcTx-Hv2a)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:11522785}.
spider