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Peptide record

TPDB27859

Neurotoxin Toxicity standard
42 amino acids
Basic Information
3D PDB MODEL
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TPDB27859
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia pep-lab
standard
No
A 42-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and pep-lab, with an available 3D structural model.
Sequence
CAKKRNWCGKTEDCCCPMKCVYAWYNEQGSCQSTISALWKKC
Physicochemical Analysis
C206H318N58O60S9
HF
C
4855.68
8.31
7
3
12
+4
4.27
-0.574
32.62
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
19980
411.48
19
Residue Composition
number
3
A
1
R
2
N
1
D
8
C
2
E
2
Q
2
G
0
H
1
I
1
L
6
K
1
M
0
F
1
P
3
S
2
T
3
W
2
Y
1
V
Amino Acid Distribution
A: 3 R: 1 N: 2 D: 1 C: 8 E: 2 Q: 2 G: 2 H: 0 I: 1 L: 1 K: 6 M: 1 F: 0 P: 1 S: 3 T: 2 W: 3 Y: 2 V: 1
Chemical Descriptors
42
C206H318N58O60S9
4855.68
8.31
+4
4.27
-0.574
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Inhibits tetrodotoxin-sensitive voltage-gated sodium channels (Nav) by binding to site 3. Slows the inactivation, and causes a prolongation of action potential duration resulting in repetitive firing in autonomic and motor nerve fibers. Does not depolarize the resting potential. Does not affect tetrodotoxin-resistant sodium channels. This lethal neurotoxin is active on both insect and mammalian voltage-gated sodium channels. Pan-neuronal expression in Drosophila is lethal but flies engineered to express the toxin only in pacemaker neurons have profound defects in circadian rhythm but a normal lifespan. {ECO:0000269|PubMed:11171353, ECO:0000269|PubMed:11874465, ECO:0000269|PubMed:18986214, ECO:0000269|PubMed:7816562, ECO:0000269|PubMed:8281423, ECO:0000269|PubMed:9028001, ECO:0000269|PubMed:9845331}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Hadronyche versuta (Blue mountains funnel-web spider) (Atrax versutus)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Inhibits tetrodotoxin-sensitive voltage-gated sodium channels (Nav) by binding to site 3. Slows the inactivation, and causes a prolongation of action potential duration resulting in repetitive firing in autonomic and motor nerve fibers.
Delta-hexatoxin-Hv1a (Delta-HXTX-Hv1a) (Delta-atracotoxin-Hv1) (Delta-ACTX-Hv1) (Delta-atracotoxin-Hv1a) (Delta-ACTX-Hv1a) (Delta-hexatoxin-Hv1a_2) (Delta-HXTX-Hv1a_2) (Versutoxin) (VTX)
spider
Neurotoxin 06 (delta-actx) family
Evidence at protein level
3D-structure Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:3355530}.
Additional Detail Fields 7 fields
3D-structure Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Neurotoxin 06 (delta-actx) family
Delta-hexatoxin-Hv1a (Delta-HXTX-Hv1a) (Delta-atracotoxin-Hv1) (Delta-ACTX-Hv1) (Delta-atracotoxin-Hv1a) (Delta-ACTX-Hv1a) (Delta-hexatoxin-Hv1a_2) (Delta-HXTX-Hv1a_2) (Versutoxin) (VTX)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:3355530}.
spider