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Peptide record

TPDB27858

Neurotoxin Toxicity standard
42 amino acids
Basic Information
3D PDB MODEL
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TPDB27858
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia pep-lab
standard
No
A 42-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and pep-lab, with an available 3D structural model.
Sequence
CAKKRNWCGKNEDCCCPMKCIYAWYNQQGSCQTTITGLFKKC
Physicochemical Analysis
C206H321N59O59S9
HV
C
4856.71
8.51
7
2
11
+5
3.65
-0.593
32.62
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
14480
298.14
20
Residue Composition
number
2
A
1
R
3
N
1
D
8
C
1
E
3
Q
3
G
0
H
2
I
1
L
6
K
1
M
1
F
1
P
1
S
3
T
2
W
2
Y
0
V
Amino Acid Distribution
A: 2 R: 1 N: 3 D: 1 C: 8 E: 1 Q: 3 G: 3 H: 0 I: 2 L: 1 K: 6 M: 1 F: 1 P: 1 S: 1 T: 3 W: 2 Y: 2 V: 0
Chemical Descriptors
42
C206H321N59O59S9
4856.71
8.51
+5
3.65
-0.593
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Inhibits tetrodotoxin-sensitive voltage-gated sodium channels (Nav) by binding to site 3. It slows the inactivation, causes a prolongation of action potential duration resulting in repetitive firing in autonomic and motor nerve fibers. Does not depolarize the resting potential. Does not affect tetrodotoxin-resistant sodium channels. This lethal neurotoxin is active on both insect and mammalian voltage-gated sodium channels. {ECO:0000269|PubMed:14596608, ECO:0000269|PubMed:2728033, ECO:0000269|PubMed:9560455, ECO:0000269|PubMed:9845331}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Atrax robustus (Sydney funnel-web spider)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Inhibits tetrodotoxin-sensitive voltage-gated sodium channels (Nav) by binding to site 3. It slows the inactivation, causes a prolongation of action potential duration resulting in repetitive firing in autonomic and motor nerve fibers.
Delta-hexatoxin-Ar1a (Delta-HXTX-Ar1a) (Delta-atracotoxin-Ar1) (Delta-atracotoxin-Ar1a) (Delta-ACTX-Ar1a) (Robustoxin) (RBX)
spider
Neurotoxin 06 (delta-actx) family
Evidence at protein level
3D-structure Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:3972101}.
Additional Detail Fields 7 fields
3D-structure Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Neurotoxin 06 (delta-actx) family
Delta-hexatoxin-Ar1a (Delta-HXTX-Ar1a) (Delta-atracotoxin-Ar1) (Delta-atracotoxin-Ar1a) (Delta-ACTX-Ar1a) (Robustoxin) (RBX)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:3972101}.
spider