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Peptide record

TPDB27853

Neurotoxin Toxicity standard
40 amino acids
Basic Information
3D PDB MODEL
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TPDB27853
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 pep-lab Peptipedia
standard
No
A 40-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, pep-lab, and Peptipedia, with an available 3D structural model.
Sequence
WCSTCLDLACGASRECYDPCFKAFGRAHGKCMNNKCRCYT
Physicochemical Analysis
C188H287N57O55S9
QIV
C
4514.24
8.10
7
3
12
+3
2.76
-0.323
29.50
Mammalian: 2.8 hour Yeast: 3 min E.coli: 2 min
8980
198.93
16
Residue Composition
number
4
A
3
R
2
N
2
D
8
C
1
E
0
Q
3
G
1
H
0
I
2
L
3
K
1
M
2
F
1
P
2
S
2
T
1
W
2
Y
0
V
Amino Acid Distribution
A: 4 R: 3 N: 2 D: 2 C: 8 E: 1 Q: 0 G: 3 H: 1 I: 0 L: 2 K: 3 M: 1 F: 2 P: 1 S: 2 T: 2 W: 1 Y: 2 V: 0
Chemical Descriptors
40
C188H287N57O55S9
4514.24
8.10
+3
2.76
-0.323
Evidence Records 2 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Inhibits high conductance calcium-activated potassium channels (By similarity). Reversibly inhibits Shaker B potassium channels. {ECO:0000250}.

Target

voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Tityus trivittatus (Argentinean scorpion)
Neurotoxin Calcium-activated potassium channel impairing toxin Ion channel impairing toxin Potassium channel impairing toxin
Inhibits high conductance calcium-activated potassium channels (By similarity). Reversibly inhibits Shaker B potassium channels..
Potassium channel toxin alpha-KTx 12.2 (Butantoxin) (BuTX) (TtBut)
scorpion
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 12 subfamily
Evidence at protein level
Calcium-activated potassium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom gland.
Evidence 2 Activity

Activity

Neurotoxin
FUNCTION: Inhibits high conductance calcium-activated potassium channels. Reversibly inhibits Shaker B potassium channels (By similarity). {ECO:0000250}.

Target

voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Tityus stigmurus (Brazilian scorpion)
Neurotoxin Calcium-activated potassium channel impairing toxin Ion channel impairing toxin Potassium channel impairing toxin
Inhibits high conductance calcium-activated potassium channels. Reversibly inhibits Shaker B potassium channels (By similarity)..
Potassium channel toxin alpha-KTx 12.4 (Butantoxin) (BuTX) (TstBut)
scorpion
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 12 subfamily
Evidence at protein level
Calcium-activated potassium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom gland.
Additional Detail Fields 7 fields
Calcium-activated potassium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin
Neurotoxin Calcium-activated potassium channel impairing toxin Ion channel impairing toxin Potassium channel impairing toxin
Evidence at protein level
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 12 subfamily
Potassium channel toxin alpha-KTx 12.2 (Butantoxin) (BuTX) (TtBut) Potassium channel toxin alpha-KTx 12.4 (Butantoxin) (BuTX) (TstBut)
TISSUE SPECIFICITY: Expressed by the venom gland.
scorpion