Back to search

Peptide record

TPDB27851

Neurotoxin Toxicity standard
39 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB27851
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 pep-lab Peptipedia
standard
No
A 39-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, pep-lab, and Peptipedia, with an available 3D structural model.
Sequence
TVIDVKCTSPKQCLPPCKAQFGIRAGAKCMNGKCKCYPH
Physicochemical Analysis
C181H299N53O49S7
EW
CK
4226.11
9.22
8
1
11
+6
7.47
-0.254
52.56
Mammalian: 7.2 hour Yeast: >20 hour E.coli: >10 hour
1865
44.13
13
Residue Composition
number
3
A
1
R
1
N
1
D
6
C
0
E
2
Q
3
G
1
H
2
I
1
L
6
K
1
M
1
F
4
P
1
S
2
T
0
W
1
Y
2
V
Amino Acid Distribution
A: 3 R: 1 N: 1 D: 1 C: 6 E: 0 Q: 2 G: 3 H: 1 I: 2 L: 1 K: 6 M: 1 F: 1 P: 4 S: 1 T: 2 W: 0 Y: 1 V: 2
Chemical Descriptors
39
C181H299N53O49S7
4226.11
9.22
+6
7.47
-0.254
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Potent selective inhibitor of Kv1.1/KCNA1, Kv1.2/KCNA2, Kv1.3/KCNA3 voltage-gated potassium channels (PubMed:9446567). Weak inhibitor of Kv1.6/KCNA6 potassium channel (PubMed:9446567). It also shows a weak interaction with nicotinic acetylcholine receptors (nAChR), suggesting it may weakly inhibit it (PubMed:31276191). {ECO:0000269|PubMed:9446567}.

Target

nicotinic acetylcholine receptor (nAChR) acetylcholine receptor voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Centruroides limbatus (Bark scorpion)
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Potent selective inhibitor of Kv1.1/KCNA1, Kv1.2/KCNA2, Kv1.3/KCNA3 voltage-gated potassium channels (PubMed:9446567). Weak inhibitor of Kv1.6/KCNA6 potassium channel (PubMed:9446567).
Potassium channel toxin alpha-KTx 2.5 (Hongotoxin-1) (HgTX1)
scorpion
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 02 subfamily
Evidence at protein level
3D-structure Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:9446567}.
Additional Detail Fields 7 fields
3D-structure Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Evidence at protein level
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 02 subfamily
Potassium channel toxin alpha-KTx 2.5 (Hongotoxin-1) (HgTX1)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:9446567}.
scorpion