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Peptide record

TPDB27850

Neurotoxin Toxicity standard
39 amino acids
Basic Information
3D PDB MODEL
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TPDB27850
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 pep-lab Peptipedia
standard
No
A 39-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, pep-lab, and Peptipedia, with an available 3D structural model.
Sequence
TIINVKCTSPKQCSKPCKELYGSSAGAKCMNGKCKCYNN
Physicochemical Analysis
C174H291N51O55S7
RDHFW
K
4201.95
9.17
7
1
9
+6
7.94
-0.574
42.56
Mammalian: 7.2 hour Yeast: >20 hour E.coli: >10 hour
3355
79.84
19
Residue Composition
number
2
A
0
R
4
N
0
D
6
C
1
E
1
Q
3
G
0
H
2
I
1
L
7
K
1
M
0
F
2
P
4
S
2
T
0
W
2
Y
1
V
Amino Acid Distribution
A: 2 R: 0 N: 4 D: 0 C: 6 E: 1 Q: 1 G: 3 H: 0 I: 2 L: 1 K: 7 M: 1 F: 0 P: 2 S: 4 T: 2 W: 0 Y: 2 V: 1
Chemical Descriptors
39
C174H291N51O55S7
4201.95
9.17
+6
7.94
-0.574
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Blocks voltage-gated potassium channels (mKv1.1/KCNA1 (Kd>25 nM), rKv1.2/KCNA2 (Kd=2 nM), mKv1.3/KCNA3 (Kd=1 nM), hKv1.5/KCNA5 (Kd>25 nM) and mKv3.1/KCNC1 (Kd>25 nM)) and calcium-activated potassium channels (KCa1.1/KCNMA1 and KCa3.1/KCNN4, Kd>25 nM). {ECO:0000269|PubMed:2448164, ECO:0000269|PubMed:7517498}.

Target

voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Centruroides noxius (Mexican scorpion)
Neurotoxin Calcium-activated potassium channel impairing toxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Blocks voltage-gated potassium channels (mKv1.1/KCNA1 (Kd>25 nM), rKv1.2/KCNA2 (Kd=2 nM), mKv1.3/KCNA3 (Kd=1 nM), hKv1.5/KCNA5 (Kd>25 nM) and mKv3.1/KCNC1 (Kd>25 nM)) and calcium-activated potassium channels (KCa1.1/KCNMA1 and KCa3.1/KCNN4, Kd>25 nM)..
Potassium channel toxin alpha-KTx 2.1 (Noxiustoxin) (NTx) (Toxin II.11)
scorpion
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 02 subfamily
Evidence at protein level
3D-structure Amidation Calcium-activated potassium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|Ref.1}.
Additional Detail Fields 7 fields
3D-structure Amidation Calcium-activated potassium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
Neurotoxin Calcium-activated potassium channel impairing toxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Evidence at protein level
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 02 subfamily
Potassium channel toxin alpha-KTx 2.1 (Noxiustoxin) (NTx) (Toxin II.11)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|Ref.1}.
scorpion