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Peptide record

TPDB27849

Neurotoxin Toxicity standard
39 amino acids
Basic Information
3D PDB MODEL
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TPDB27849
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 pep-lab Peptipedia
standard
No
A 39-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, pep-lab, and Peptipedia, with an available 3D structural model.
Sequence
TIINVKCTSPKQCLPPCKAQFGQSAGAKCMNGKCKCYPH
Physicochemical Analysis
C178H292N52O50S7
RDEW
CK
4185.02
9.22
7
0
10
+6
6.49
-0.356
45.13
Mammalian: 7.2 hour Yeast: >20 hour E.coli: >10 hour
1865
44.56
16
Residue Composition
number
3
A
0
R
2
N
0
D
6
C
0
E
3
Q
3
G
1
H
2
I
1
L
6
K
1
M
1
F
4
P
2
S
2
T
0
W
1
Y
1
V
Amino Acid Distribution
A: 3 R: 0 N: 2 D: 0 C: 6 E: 0 Q: 3 G: 3 H: 1 I: 2 L: 1 K: 6 M: 1 F: 1 P: 4 S: 2 T: 2 W: 0 Y: 1 V: 1
Chemical Descriptors
39
C178H292N52O50S7
4185.02
9.22
+6
6.49
-0.356
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Potent inhibitor of voltage-gated potassium channels such as Kv1.1/KCNA1 (IC(50)=0.144 nM), Kv1.2/KCNA2 (IC(50)=0.675 nM), Kv1.3/KCNA3 (IC(50)=0.23 nM) and Shaker (Kd=160 nM) (PubMed:33864815, PubMed:34919963, PubMed:8360176). Suppresses expression of the Kv1.3/KCNA3 channel in lipopolysaccharide (LPS)-stimulated mouse macrophages (PubMed:33864815). Down-regulates secretion of nitric oxide (NO) and inflammatory cytokines, such as TNF/TNF, IL-1beta/IL1B and IL6, in LPS-stimulated mouse macrophages in a manner dependent on Kv1.3/KCNA3 channel blockage (PubMed:33864815). Reduces activation of MAPK and NF-kappa-B signaling pathways in LPS-stimulated mouse macrophages (PubMed:33864815). Modulates intracellular Ca(2+) signaling in human PMA/ionomycin-triggered T-cells (PubMed:34919963). Interferes with the activation of the MAPK, NF-kappa-B and NFATc1 pathways in human PMA/ionomycin-triggered T-cells (PubMed:34919963). Reduces proliferation of human PMA/ionomycin-triggered T-cells (PubMed:34919963). Down-regulates secretion of cytokines, such as TNF/TNF and IL2, in human PMA/ionomycin-triggered T-cells (PubMed:34919963). {ECO:0000269|PubMed:33864815, ECO:0000269|PubMed:34919963, ECO:0000269|PubMed:8360176}.

Target

voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Centruroides margaritatus (Central American bark Scorpion)
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Potent inhibitor of voltage-gated potassium channels such as Kv1.1/KCNA1 (IC(50)=0.144 nM), Kv1.2/KCNA2 (IC(50)=0.675 nM), Kv1.3/KCNA3 (IC(50)=0.23 nM) and Shaker (Kd=160 nM) (PubMed:33864815, PubMed:34919963, PubMed:8360176). Suppresses expression of the Kv1.3/KCNA3 channel in lipopolysaccharide (LPS)-stimulated mouse macrophages (PubMed:33864815).
Potassium channel toxin alpha-KTx 2.2 (Margatoxin) (MgTX)
scorpion
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 02 subfamily
Evidence at protein level
3D-structure Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:8360176}.
Additional Detail Fields 7 fields
3D-structure Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Evidence at protein level
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 02 subfamily
Potassium channel toxin alpha-KTx 2.2 (Margatoxin) (MgTX)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:8360176}.
scorpion