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Peptide record

TPDB27847

Exendin-4 Blood-Brain Barrier Toxicity standard

39 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB27847

Peptide_Name

Exendin-4

Activity

Blood-Brain Barrier Toxicity

Activity_category_statistics

Toxicity and safety peptides Delivery and barrier-penetrating peptides

Database_Source

BBPpredict Peptipedia pep-lab PEPlife

Sequence_Type

standard

Has_Modification No

Description A 39-aa standard natural multi-activity (Blood-Brain Barrier and Toxicity) peptide sequence curated from BBPpredict, Peptipedia, pep-lab, and other sources, with an available 3D structural model.

Sequence

HGEGTFTSDLSKQMEEEAVRLFIEWLKNGGPSSGAPPPS

FASTA

>TPDB27847|Blood-Brain Barrier;Toxicity|length=39
HGEGTFTSDLSKQMEEEAVRLFIEWLKNGGPSSGAPPPS

Formula C184H281N49O61S1

Absent Amino Acids CY

Common Amino Acids EGS

Mass 4187.61

PI 4.49

Basic Residues 4

Acidic Residues 6

Hydrophobic Residues 11

Net Charge -3

Boman Index 12.26

Hydrophobicity -0.692

Aliphatic Index 52.56

Half Life

Mammalian: 3.5 hour Yeast: 10 min E.coli: >10 hour

Extinction Coefficient Cystines 5500

Absorbance 280nm 131.34

Polar Residues 9

number

Amino Acid Distribution

A: 2 R: 1 N: 1 D: 1 C: 0 E: 5 Q: 1 G: 5 H: 1 I: 1 L: 3 K: 2 M: 1 F: 2 P: 4 S: 5 T: 2 W: 1 Y: 0 V: 1

Length

Formula

C184H281N49O61S1

Mass

4187.61

4.49

Net Charge

-3

Boman Index

12.26

Hydrophobicity

-0.692

Conformation

Linear

Peptide_Length

Similarity

Peptide_Sequence_3Letter

His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser

SMILES

CCC(C)C(C(=O)NC(CCC(=O)O)C(=O)NC(CC1=CNC2=CC=CC=C21)C(=O)NC(CC(C)C)C(=O) NC(CCCCN)C(=O)NC(CC(=O)N)C(=O)NCC(=O)NCC(=O)N3CCCC3C(=O)NC(CO)C(=O)NC (CO)C(=O)NCC(=O)NC(C)C(=O)N4CCCC4C(=O)N5CCCC5C(=O)N6CCCC6C(=O)NC(CO)C(= O)N)NC(=O)C(CC7=CC=CC=C7)NC(=O)C(CC(C)C)NC(=O)C(CCCNC(=N)N)NC(=O)C(C(C) C)NC(=O)C(C)NC(=O)C(CCC(=O)O)NC(=O)C(CCC(=O)O)NC(=O)C(CCC(=O)O)NC(=O)C (CCSC)NC(=O)C(CCC(=O)N)NC(=O)C(CCCCN)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C (CC(=O)O)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C(CC8=CC=CC=C8)NC(=O)C(C(C)O)NC (=O)CNC(=O)C(CCC(=O)O)NC(=O)CNC(=O)C(CC9=CN=CN9)N

Evidence 1 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 0.0004621 mL/(g x min)

Assay & Model

Animal Model Origin/Source

Response Unidirectional influx rate constant

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin human,bovine,mouse,rat,porcine

In Vivo Mode of Delivery Intravenous

Transport Type Saturable

Label Direct iodination

Evidence 2 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 0.047 min-1

Assay & Model

In Vitro Method Efflux study ICU

Animal Model Origin/Source

Response Brain elemination rate constant

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin human,bovine,mouse,rat,porcine

Transport Type Permeability

Label Direct iodination

Evidence 3 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 14.6 min

Assay & Model

In Vitro Method Efflux study ICU

Animal Model Origin/Source

Response half life, brain

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin human,bovine,mouse,rat,porcine

Transport Type Permeability

Label Direct iodination

Evidence 4 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 0.01895 mL/(g x min)

Assay & Model

Animal Model Origin/Source

Response Unidirectional flux rate constant

Source & Reference

Database Source NA

Source B3Pdb

Other

Source B3Pdb

Other

Source Origin human,bovine,mouse,rat,porcine

Label Direct iodination

Experiment context

Radioimmunoassay

Experiment_modality

in vitro

Half-life seconds

8640.0

Half-life unit

hours

Hydrophobicity

N.A.

In_Vivo_Mode_of_Delivery

Intravenous in situ brain perfusion

Molecular Weight (Daltons)

4186.6

N.A.