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Peptide record

TPDB27840

Neurotoxin Toxicity standard
38 amino acids
Basic Information
3D PDB MODEL
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TPDB27840
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 pep-lab Peptipedia
standard
No
A 38-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, pep-lab, and Peptipedia, with an available 3D structural model.
Sequence
GVIINVKCKISRQCLEPCKKAGMRFGKCMNGKCHCTPK
Physicochemical Analysis
C177H306N56O46S8
DWY
K
4211.20
9.94
10
1
10
+8
9.61
-0.282
58.95
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
375
8.90
11
Residue Composition
number
1
A
2
R
2
N
0
D
6
C
1
E
1
Q
4
G
1
H
3
I
1
L
7
K
2
M
1
F
2
P
1
S
1
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 1 R: 2 N: 2 D: 0 C: 6 E: 1 Q: 1 G: 4 H: 1 I: 3 L: 1 K: 7 M: 2 F: 1 P: 2 S: 1 T: 1 W: 0 Y: 0 V: 2
Chemical Descriptors
38
C177H306N56O46S8
4211.20
9.94
+8
9.61
-0.282
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Blocks voltage-gated potassium channels Kv1.1/KCNA1 (IC(50)=0.6 nM), Kv1.2/KCNA2 (IC(50)=5.4 nM), Kv1.3/KCNA3 (IC(50)=0.014 nM) potently, and moderately block intermediate conductance calcium-activated potassium channels KCa3.1/KCNN4 (IC(50)=225 nM) (PubMed:15588251, PubMed:16234482, Ref.1). Also shows activity on muscle-type nicotinic acetylcholine receptor (nAChR), since it reversibly and dose-dependently inhibits acetylcholine-induced current through mouse muscle-type nAChR heterologously expressed in Xenopus oocytes (IC(50)=1.6 uM) (PubMed:31276191). {ECO:0000269|PubMed:15588251, ECO:0000269|PubMed:16234482, ECO:0000269|PubMed:31276191, ECO:0000269|Ref.1}.

Target

nicotinic acetylcholine receptor (nAChR) acetylcholine receptor voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Orthochirus scrobiculosus (Central Asian scorpion)
Neurotoxin Calcium-activated potassium channel impairing toxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Blocks voltage-gated potassium channels Kv1.1/KCNA1 (IC(50)=0.6 nM), Kv1.2/KCNA2 (IC(50)=5.4 nM), Kv1.3/KCNA3 (IC(50)=0.014 nM) potently, and moderately block intermediate conductance calcium-activated potassium channels KCa3.1/KCNN4 (IC(50)=225 nM) (PubMed:15588251, PubMed:16234482, Ref.1). Also shows activity on muscle-type nicotinic acetylcholine receptor (nAChR), since it reversibly and dose-dependently inhibits acetylcholine-induced current through mouse muscle-type nAChR heterologously expressed in Xenopus oocytes (IC(50)=1.6 uM) (PubMed:31276191)..
Potassium channel toxin alpha-KTx 3.7 (OsK-1) (OsK1)
scorpion
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 03 subfamily
Evidence at protein level
3D-structure Calcium-activated potassium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|Ref.1}.
Additional Detail Fields 7 fields
3D-structure Calcium-activated potassium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
Neurotoxin Calcium-activated potassium channel impairing toxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Evidence at protein level
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 03 subfamily
Potassium channel toxin alpha-KTx 3.7 (OsK-1) (OsK1)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|Ref.1}.
scorpion