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Peptide record

TPDB27839

Neurotoxin Toxicity standard
38 amino acids
Basic Information
3D PDB MODEL
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TPDB27839
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 pep-lab Peptipedia
standard
No
A 38-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, pep-lab, and Peptipedia, with an available 3D structural model.
Sequence
GVEINVKCSGSPQCLKPCKDAGMRFGKCMNRKCHCTPK
Physicochemical Analysis
C171H289N55O49S8
WY
CK
4155.99
9.27
9
2
8
+6
11.05
-0.571
38.42
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
375
9.02
12
Residue Composition
number
1
A
2
R
2
N
1
D
6
C
1
E
1
Q
4
G
1
H
1
I
1
L
6
K
2
M
1
F
3
P
2
S
1
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 1 R: 2 N: 2 D: 1 C: 6 E: 1 Q: 1 G: 4 H: 1 I: 1 L: 1 K: 6 M: 2 F: 1 P: 3 S: 2 T: 1 W: 0 Y: 0 V: 2
Chemical Descriptors
38
C171H289N55O49S8
4155.99
9.27
+6
11.05
-0.571
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Potent inhibitor voltage-gated potassium channels Kv1.3/KCNA3 (Kd=0.65 nM) and Kv1.1/KCNA1 (Kd=41 nM) (PubMed:7517498). It appears to block channel activity by a simple bimolecular inhibition process. Induces a transient period of fast flickering in the channel openings, followed by an almost complete blockade of the channel. Its binding affinity to rat brain synaptosomes is 5-fold higher than this of KTX-3. Binding of the toxin to the channel is associated with significant structural rearrangements in both molecules. It also shows a weak interaction with nicotinic acetylcholine receptors (nAChR), suggesting it may weakly inhibit it (PubMed:31276191). {ECO:0000269|PubMed:1730708, ECO:0000269|PubMed:7517498}.

Target

nicotinic acetylcholine receptor (nAChR) acetylcholine receptor voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Androctonus mauritanicus mauritanicus (Scorpion)
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Potent inhibitor voltage-gated potassium channels Kv1.3/KCNA3 (Kd=0.65 nM) and Kv1.1/KCNA1 (Kd=41 nM) (PubMed:7517498). It appears to block channel activity by a simple bimolecular inhibition process.
Potassium channel toxin alpha-KTx 3.1 (Kaliotoxin) (KTX) (Kaliotoxin-1) (KTX-1)
scorpion
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 03 subfamily
Evidence at protein level
3D-structure Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:1730708}.
Additional Detail Fields 7 fields
3D-structure Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Evidence at protein level
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 03 subfamily
Potassium channel toxin alpha-KTx 3.1 (Kaliotoxin) (KTX) (Kaliotoxin-1) (KTX-1)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:1730708}.
scorpion