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Peptide record

TPDB27834

Neurotoxin Toxicity standard
37 amino acids
Basic Information
3D PDB MODEL
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TPDB27834
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 pep-lab Peptipedia
standard
No
A 37-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, pep-lab, and Peptipedia, with an available 3D structural model.
Sequence
VCRDWFKETACRHAKSLGNCRTSQKYRANCAKTCELC
Physicochemical Analysis
C177H287N59O53S6
IMP
C
4281.95
8.89
9
3
10
+5
8.45
-0.738
39.73
Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour
7365
172.00
15
Residue Composition
number
4
A
4
R
2
N
1
D
6
C
2
E
1
Q
1
G
1
H
0
I
2
L
4
K
0
M
1
F
0
P
2
S
3
T
1
W
1
Y
1
V
Amino Acid Distribution
A: 4 R: 4 N: 2 D: 1 C: 6 E: 2 Q: 1 G: 1 H: 1 I: 0 L: 2 K: 4 M: 0 F: 1 P: 0 S: 2 T: 3 W: 1 Y: 1 V: 1
Chemical Descriptors
37
C177H287N59O53S6
4281.95
8.89
+5
8.45
-0.738
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Inhibits voltage-dependent potassium channels of the Kv1 family (Kv1.1/KCNA1 (Kd=6 nM), Kv1.2/KCNA2 (Kd=15 nM), Kv1.3/KCNA3 (Kd=10-39 nM), Kv1.6/KCNA6, and KCa3.1/KCNN4 (Kd=172 nM)). {ECO:0000269|PubMed:10419508, ECO:0000269|PubMed:10585444, ECO:0000269|PubMed:11707459, ECO:0000269|PubMed:8098956}.

Target

voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Bunodosoma granuliferum (Red warty sea anemone)
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Inhibits voltage-dependent potassium channels of the Kv1 family (Kv1.1/KCNA1 (Kd=6 nM), Kv1.2/KCNA2 (Kd=15 nM), Kv1.3/KCNA3 (Kd=10-39 nM), Kv1.6/KCNA6, and KCa3.1/KCNN4 (Kd=172 nM))..
Kappa-actitoxin-Bgr1a (Kappa-AITX-Bgr1a) (Potassium channel toxin Bgk)
sea anemone
Sea anemone type 1 potassium channel toxin family, Type 1b subfamily
Evidence at protein level
3D-structure Direct protein sequencing Disulfide bond Ion channel impairing toxin Nematocyst Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
Additional Detail Fields 6 fields
3D-structure Direct protein sequencing Disulfide bond Ion channel impairing toxin Nematocyst Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Evidence at protein level
Sea anemone type 1 potassium channel toxin family, Type 1b subfamily
Kappa-actitoxin-Bgr1a (Kappa-AITX-Bgr1a) (Potassium channel toxin Bgk)
sea anemone