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Peptide record

TPDB27833

Neurotoxin Toxicity standard
37 amino acids
Basic Information
3D PDB MODEL
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TPDB27833
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia pep-lab
standard
No
A 37-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and pep-lab, with an available 3D structural model.
Sequence
SPTCIPSGQPCPYNENCCSQSCTFKENENGNTVKRCD
Physicochemical Analysis
C162H253N49O61S6
AHLMW
C
4055.44
4.65
3
4
4
-1
12.35
-1.030
18.38
Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour
1865
45.99
21
Residue Composition
number
0
A
1
R
5
N
1
D
6
C
3
E
2
Q
2
G
0
H
1
I
0
L
2
K
0
M
1
F
4
P
4
S
3
T
0
W
1
Y
1
V
Amino Acid Distribution
A: 0 R: 1 N: 5 D: 1 C: 6 E: 3 Q: 2 G: 2 H: 0 I: 1 L: 0 K: 2 M: 0 F: 1 P: 4 S: 4 T: 3 W: 0 Y: 1 V: 1
Chemical Descriptors
37
C162H253N49O61S6
4055.44
4.65
-1
12.35
-1.030
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Reversibly and voltage-independently blocks both mid-low- (M-LVA) and high-voltage-activated (HVA) calcium channels in cockroach DUM neurons (PubMed:17610847). Is lethal to many insect species but not toxic to mammals (PubMed:16779650, PubMed:9228949). May target the insect high-voltage-activated calcium channel Dmca1D. Also inhibits acarines calcium channels. An extremely high toxin concentration partially inhibits Cav1.2/CACNA1C, Cav2.1/CACNA1A and Cav2.2/CACNA1B calcium channel of rats. As for omega-AcTx-Hv2a, the phenotypic effect of injection of this toxin into lone star ticks (Amblyomma americanum) is curling of all eight legs into closed loops. {ECO:0000269|PubMed:14608494, ECO:0000269|PubMed:15308644, ECO:0000269|PubMed:16330063, ECO:0000269|PubMed:17141372, ECO:0000269|PubMed:17610847, ECO:0000269|PubMed:9228949}.

Target

voltage-gated calcium channel (Cav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Hadronyche versuta (Blue mountains funnel-web spider) (Atrax versutus)
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Reversibly and voltage-independently blocks both mid-low- (M-LVA) and high-voltage-activated (HVA) calcium channels in cockroach DUM neurons (PubMed:17610847). Is lethal to many insect species but not toxic to mammals (PubMed:16779650, PubMed:9228949).
Omega-hexatoxin-Hv1a (Omega-HXTX-Hv1a) (Omega-atracotoxin-Hv1a) (Omega-ACTX-Hv1) (Omega-AcTx-Hv1a) (Omega-atracotoxin-Hv1) (Omega/kappa-atracotoxin-Hv1a) (Omega/kappa-HXTX-Hv1a)
spider
Neurotoxin 08 (Shiva) family, 01 (omega toxin) subfamily
Evidence at protein level
3D-structure Calcium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin Voltage-gated calcium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:9228949}.
Additional Detail Fields 7 fields
3D-structure Calcium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin Voltage-gated calcium channel impairing toxin
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Evidence at protein level
Neurotoxin 08 (Shiva) family, 01 (omega toxin) subfamily
Omega-hexatoxin-Hv1a (Omega-HXTX-Hv1a) (Omega-atracotoxin-Hv1a) (Omega-ACTX-Hv1) (Omega-AcTx-Hv1a) (Omega-atracotoxin-Hv1) (Omega/kappa-atracotoxin-Hv1a) (Omega/kappa-HXTX-Hv1a)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:9228949}.
spider