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Peptide record

TPDB27827

Neurotoxin Toxicity standard
37 amino acids
Basic Information
3D PDB MODEL
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TPDB27827
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia pep-lab
standard
No
A 37-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and pep-lab, with an available 3D structural model.
Sequence
GCLGEGEKCADWSGPSCCDGFYCSCRSMPYCRCRNNS
Physicochemical Analysis
C161H242N50O55S9
QHITV
C
4046.53
6.06
4
4
7
-0
4.62
-0.562
13.24
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
8980
221.92
17
Residue Composition
number
1
A
3
R
2
N
2
D
8
C
2
E
0
Q
5
G
0
H
0
I
1
L
1
K
1
M
1
F
2
P
5
S
0
T
1
W
2
Y
0
V
Amino Acid Distribution
A: 1 R: 3 N: 2 D: 2 C: 8 E: 2 Q: 0 G: 5 H: 0 I: 0 L: 1 K: 1 M: 1 F: 1 P: 2 S: 5 T: 0 W: 1 Y: 2 V: 0
Chemical Descriptors
37
C161H242N50O55S9
4046.53
6.06
-0
4.62
-0.562
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Binds at site 4 of sodium channels (Nav) and inhibits the fast inactivation of cockroach channels. This toxin is active only on insects. Has a potent activity against S.litura larvae. {ECO:0000269|PubMed:10971590}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Pireneitega luctuosa (Tangled nest spider) (Paracoelotes luctuosus)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Binds at site 4 of sodium channels (Nav) and inhibits the fast inactivation of cockroach channels. This toxin is active only on insects.
Delta-amaurobitoxin-Pl1a (Delta-AMATX-Pl1a) (Delta-palutoxin IT1) (Delta-paluIT1)
spider
Neurotoxin 07 (Beta/delta-agtx) family, 02 (aga-3) subfamily
Evidence at protein level
3D-structure Amidation Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:10971590}.
Additional Detail Fields 7 fields
3D-structure Amidation Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Neurotoxin 07 (Beta/delta-agtx) family, 02 (aga-3) subfamily
Delta-amaurobitoxin-Pl1a (Delta-AMATX-Pl1a) (Delta-palutoxin IT1) (Delta-paluIT1)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:10971590}.
spider