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Peptide record

TPDB27821

Neurotoxin Toxicity standard
37 amino acids
Basic Information
3D PDB MODEL
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TPDB27821
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia pep-lab
standard
No
A 37-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and pep-lab, with an available 3D structural model.
Sequence
AICTGADRPCAACCPCCPGTSCKAESNGVSYCRKDEP
Physicochemical Analysis
C148H240N46O53S8
QHLMFW
C
3768.29
6.06
4
4
8
-0
9.07
-0.251
31.89
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
1990
52.81
15
Residue Composition
number
5
A
2
R
1
N
2
D
8
C
2
E
0
Q
3
G
0
H
1
I
0
L
2
K
0
M
0
F
4
P
3
S
2
T
0
W
1
Y
1
V
Amino Acid Distribution
A: 5 R: 2 N: 1 D: 2 C: 8 E: 2 Q: 0 G: 3 H: 0 I: 1 L: 0 K: 2 M: 0 F: 0 P: 4 S: 3 T: 2 W: 0 Y: 1 V: 1
Chemical Descriptors
37
C148H240N46O53S8
3768.29
6.06
-0
9.07
-0.251
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: This excitatory toxin inhibits insect calcium-activated potassium (KCa) channels (Slo-type). Pan-neuronal expression in Drosophila is lethal but flies engineered to express the toxin only in clock neurons have defects in circadian rhythm but a normal lifespan. {ECO:0000269|PubMed:10881200, ECO:0000269|PubMed:17141372, ECO:0000269|PubMed:18625007, ECO:0000269|PubMed:18986214}.

Target

voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Hadronyche versuta (Blue mountains funnel-web spider) (Atrax versutus)
Neurotoxin Calcium-activated potassium channel impairing toxin Ion channel impairing toxin Potassium channel impairing toxin
This excitatory toxin inhibits insect calcium-activated potassium (KCa) channels (Slo-type). Pan-neuronal expression in Drosophila is lethal but flies engineered to express the toxin only in clock neurons have defects in circadian rhythm but a normal lifespan..
Lambda-hexatoxin-Hv1c (Lambda-HXTX-Hv1c) (Janus-atracotoxin-Hv1c) (Janus-AcTx-Hv1c) (Kappa-atracotoxin-Hv1c) (Kappa-AcTx-Hv1c) (Kappa-hexatoxin-Hv1c) (Kappa-HXTX-Hv1c)
spider
Neurotoxin 11 (kappa toxin) family
Evidence at protein level
3D-structure Calcium-activated potassium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Potassium channel impairing toxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:10881200}.
Additional Detail Fields 7 fields
3D-structure Calcium-activated potassium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Potassium channel impairing toxin Secreted Toxin
Neurotoxin Calcium-activated potassium channel impairing toxin Ion channel impairing toxin Potassium channel impairing toxin
Evidence at protein level
Neurotoxin 11 (kappa toxin) family
Lambda-hexatoxin-Hv1c (Lambda-HXTX-Hv1c) (Janus-atracotoxin-Hv1c) (Janus-AcTx-Hv1c) (Kappa-atracotoxin-Hv1c) (Kappa-AcTx-Hv1c) (Kappa-hexatoxin-Hv1c) (Kappa-HXTX-Hv1c)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:10881200}.
spider