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Peptide record

TPDB27815

Neurotoxin Toxicity standard
36 amino acids
Basic Information
3D PDB MODEL
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TPDB27815
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia pep-lab
standard
No
A 36-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and pep-lab, with an available 3D structural model.
Sequence
EGECGGFWWKCGSGKPACCPKYVCSPKWGLCNFPMP
Physicochemical Analysis
C178H254N44O45S7
RDQHIT
CG
3954.66
8.02
4
2
10
+2
-0.09
-0.272
21.67
Mammalian: 1 hour Yeast: 30 min E.coli: >10 hour
18365
464.39
10
Residue Composition
number
1
A
0
R
1
N
0
D
6
C
2
E
0
Q
6
G
0
H
0
I
1
L
4
K
1
M
2
F
5
P
2
S
0
T
3
W
1
Y
1
V
Amino Acid Distribution
A: 1 R: 0 N: 1 D: 0 C: 6 E: 2 Q: 0 G: 6 H: 0 I: 0 L: 1 K: 4 M: 1 F: 2 P: 5 S: 2 T: 0 W: 3 Y: 1 V: 1
Chemical Descriptors
36
C178H254N44O45S7
3954.66
8.02
+2
-0.09
-0.272
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Gating modifier of Kv2.1/KCNB1 (IC(50)=5.1 nM), Kv2.2/KCNB2 and Kv4.3/KCND3 channels (IC(50)=39 nM). Acts by shifting the channel activation to more depolarized potentials by stabilizing the resting conformation of the voltage sensor. It completely inhibits opening of the Kv2.1/KCNB1 channel at negative membrane voltages and dramatically shifts channel activation to positive voltages. May act by partitioning into lipid membranes and then by binding the voltage sensor paddle of the channel from a place within the membrane. {ECO:0000269|PubMed:16567526, ECO:0000269|PubMed:17101164, ECO:0000269|PubMed:21150283}.

Target

voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Chilobrachys guangxiensis (Chinese earth tiger tarantula) (Chilobrachys jingzhao)
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Gating modifier of Kv2.1/KCNB1 (IC(50)=5.1 nM), Kv2.2/KCNB2 and Kv4.3/KCND3 channels (IC(50)=39 nM). Acts by shifting the channel activation to more depolarized potentials by stabilizing the resting conformation of the voltage sensor.
Kappa-theraphotoxin-Pg1a (Kappa-TRTX-Pg1a) (Guangxitoxin-1E) (GxTx1E)
spider
Neurotoxin 10 (Hwtx-1) family, 44 (Jztx-4) subfamily
Evidence at protein level
3D-structure Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000269|PubMed:16567526}.
Additional Detail Fields 7 fields
3D-structure Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Evidence at protein level
Neurotoxin 10 (Hwtx-1) family, 44 (Jztx-4) subfamily
Kappa-theraphotoxin-Pg1a (Kappa-TRTX-Pg1a) (Guangxitoxin-1E) (GxTx1E)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000269|PubMed:16567526}.
spider