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Peptide record

TPDB27807

Neurotoxin Toxicity standard
35 amino acids
Basic Information
3D PDB MODEL
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TPDB27807
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 pep-lab Peptipedia ToxinPred 3.0
standard
No
A 35-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, pep-lab, Peptipedia, and other sources, with an available 3D structural model.
Sequence
TISCTNEKQCYPHCKKETGYPNAKCMNRKCKCFGR
Physicochemical Analysis
C169H273N53O50S7
DLWV
CK
4071.77
9.18
9
2
6
+6
10.71
-1.146
14.00
Mammalian: 7.2 hour Yeast: >20 hour E.coli: >10 hour
3355
82.40
16
Residue Composition
number
1
A
2
R
3
N
0
D
6
C
2
E
1
Q
2
G
1
H
1
I
0
L
6
K
1
M
1
F
2
P
1
S
3
T
0
W
2
Y
0
V
Amino Acid Distribution
A: 1 R: 2 N: 3 D: 0 C: 6 E: 2 Q: 1 G: 2 H: 1 I: 1 L: 0 K: 6 M: 1 F: 1 P: 2 S: 1 T: 3 W: 0 Y: 2 V: 0
Chemical Descriptors
35
C169H273N53O50S7
4071.77
9.18
+6
10.71
-1.146
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Potent inhibitor of the A-type voltage-gated potassium channels. Most potent inhibitor of Kv1.2/KCNA2 channels. Reversibly block the Shaker B potassium-channels (Kv1.1 sub-family), but with a lower affinity than PiTX-K alpha. {ECO:0000269|PubMed:8660410}.

Target

voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Pandinus imperator (Emperor scorpion)
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Potent inhibitor of the A-type voltage-gated potassium channels. Most potent inhibitor of Kv1.2/KCNA2 channels.
Potassium channel toxin alpha-KTx 7.2 (Pandinotoxin-beta) (Potassium channel-blocking toxin 3) (Pi-3) (Pi3) (Toxin PiTX-K-beta)
scorpion
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 07 subfamily
Evidence at protein level
3D-structure Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland.
Additional Detail Fields 7 fields
3D-structure Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Evidence at protein level
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 07 subfamily
Potassium channel toxin alpha-KTx 7.2 (Pandinotoxin-beta) (Potassium channel-blocking toxin 3) (Pi-3) (Pi3) (Toxin PiTX-K-beta)
TISSUE SPECIFICITY: Expressed by the venom gland.
scorpion