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Peptide record

TPDB27805

Neurotoxin Toxicity standard
35 amino acids
Basic Information
3D PDB MODEL
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TPDB27805
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 pep-lab Peptipedia ToxinPred 3.0
standard
No
A 35-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, pep-lab, Peptipedia, and other sources, with an available 3D structural model.
Sequence
RSCIDTIPKSRCTAFQCKHSMKYRLSFCRKTCGTC
Physicochemical Analysis
C169H280N54O48S7
NEWV
C
4060.84
9.66
9
1
8
+7
5.29
-0.457
36.29
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
1865
45.93
16
Residue Composition
number
1
A
4
R
0
N
1
D
6
C
0
E
1
Q
1
G
1
H
2
I
1
L
4
K
1
M
2
F
1
P
4
S
4
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 1 R: 4 N: 0 D: 1 C: 6 E: 0 Q: 1 G: 1 H: 1 I: 2 L: 1 K: 4 M: 1 F: 2 P: 1 S: 4 T: 4 W: 0 Y: 1 V: 0
Chemical Descriptors
35
C169H280N54O48S7
4060.84
9.66
+7
5.29
-0.457
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Peptide with both antimicrobial and neurotoxin activities. Inhibits voltage-dependent potassium channels. Potently blocks Kv1.1/KCNA1 (IC(50)=6.7-87 pM) and Kv1.3/KCNA3 (IC(50)=10-250 pM) (PubMed:10545177, PubMed:15665253, PubMed:23919482, PubMed:26288216, PubMed:28194851, PubMed:8567178, PubMed:9830012). Less potently blocks Kv1.4/KCNA4 (IC(50)=0.31 nM), and Kv1.6/KCNA6 (IC(50)=0.16 nM) (PubMed:9830012). Shows moderate activity on Kv1.2/KCNA2 (IC(50)=9 nM), Kv1.7/KCNA7 (IC(50)=11.5 nM), and KCa3.1/KCNN4 (Kd=0.03-30 nM) (PubMed:10419508, PubMed:9830012). Blocks Kv channels by binding to a shallow vestibule at the outer entrance to the ion conduction pathway and occluding the entrance to the pore (PubMed:10419508, PubMed:9830012). Shows antibacterial activity against all tested bacteria (the Gram-positive bacteria B.subtilis and S.aureus, and the Gram-negative bacteria S.typhimurium and P.aeruginosa) (PubMed:28796463). {ECO:0000269|PubMed:10419508, ECO:0000269|PubMed:10545177, ECO:0000269|PubMed:15665253, ECO:0000269|PubMed:23919482, ECO:0000269|PubMed:26288216, ECO:0000269|PubMed:28194851, ECO:0000269|PubMed:7660365, ECO:0000269|PubMed:8567178, ECO:0000269|PubMed:9830012}.

Target

voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Stichodactyla helianthus (Sun anemone) (Stoichactis helianthus)
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Peptide with both antimicrobial and neurotoxin activities. Inhibits voltage-dependent potassium channels.
Kappa-stichotoxin-She3a (Kappa-SHTX-She3a) (Potassium channel toxin ShK)
sea anemone
Sea anemone type 1 potassium channel toxin family, Type 1a subfamily
Evidence at protein level
3D-structure Antibiotic Antimicrobial Direct protein sequencing Disulfide bond Ion channel impairing toxin Nematocyst Neurotoxin Pharmaceutical Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
Additional Detail Fields 6 fields
3D-structure Antibiotic Antimicrobial Direct protein sequencing Disulfide bond Ion channel impairing toxin Nematocyst Neurotoxin Pharmaceutical Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Evidence at protein level
Sea anemone type 1 potassium channel toxin family, Type 1a subfamily
Kappa-stichotoxin-She3a (Kappa-SHTX-She3a) (Potassium channel toxin ShK)
sea anemone