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Peptide record

TPDB27801

Neurotoxin Toxicity standard
35 amino acids
Basic Information
3D PDB MODEL
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TPDB27801
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 pep-lab Peptipedia ToxinPred 3.0
standard
No
A 35-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, pep-lab, Peptipedia, and other sources, with an available 3D structural model.
Sequence
LVKCRGTSDCGRPCQQQTGCPNSKCINRMCKCYGC
Physicochemical Analysis
C150H254N52O48S9
AEHFW
C
3842.53
8.52
6
1
5
+5
6.80
-0.597
30.57
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
1990
51.79
18
Residue Composition
number
0
A
3
R
2
N
1
D
8
C
0
E
3
Q
4
G
0
H
1
I
1
L
3
K
1
M
0
F
2
P
2
S
2
T
0
W
1
Y
1
V
Amino Acid Distribution
A: 0 R: 3 N: 2 D: 1 C: 8 E: 0 Q: 3 G: 4 H: 0 I: 1 L: 1 K: 3 M: 1 F: 0 P: 2 S: 2 T: 2 W: 0 Y: 1 V: 1
Chemical Descriptors
35
C150H254N52O48S9
3842.53
8.52
+5
6.80
-0.597
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Potently and reversibly inhibits the insect voltage-gated Shaker (Sh) potassium channel (isoform alpha (B)), the mammalian voltage-gated potassium channels Kv1.2/KCNA2 (IC(50)=0.44 nM), and the calcium-activated potassium channel KCa2.3/KCNN3 (Kd=330 nM) (PubMed:10931199, PubMed:11527975, PubMed:9001397). Its effect on Kv1.3/KCNA3 is controversial, since this channel is voltage-independently inhibited in PubMed:9464266, but is not affected in PubMed:10931199. Furthermore, this toxin competes with apamin (a small conductance calcium-activated potassium channel inhibitor) for binding to rat brain synaptosomes. {ECO:0000269|PubMed:10931199, ECO:0000269|PubMed:11527975, ECO:0000269|PubMed:8645186, ECO:0000269|PubMed:9001397, ECO:0000269|PubMed:9464266}.

Target

voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Pandinus imperator (Emperor scorpion)
Neurotoxin Calcium-activated potassium channel impairing toxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Potently and reversibly inhibits the insect voltage-gated Shaker (Sh) potassium channel (isoform alpha (B)), the mammalian voltage-gated potassium channels Kv1.2/KCNA2 (IC(50)=0.44 nM), and the calcium-activated potassium channel KCa2.3/KCNN3 (Kd=330 nM) (PubMed:10931199, PubMed:11527975, PubMed:9001397). Its effect on Kv1.3/KCNA3 is controversial, since this channel is voltage-independently inhibited in PubMed:9464266, but is not affected in PubMed:10931199.
Potassium channel toxin alpha-KTx 6.1 (PiTX-K-gamma) (Potassium channel-blocking toxin 1) (Pi-1) (Pi1)
scorpion
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 06 subfamily
Evidence at protein level
3D-structure Calcium-activated potassium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:8645186, ECO:0000305|PubMed:8913348}.
Additional Detail Fields 7 fields
3D-structure Calcium-activated potassium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
Neurotoxin Calcium-activated potassium channel impairing toxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Evidence at protein level
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 06 subfamily
Potassium channel toxin alpha-KTx 6.1 (PiTX-K-gamma) (Potassium channel-blocking toxin 1) (Pi-1) (Pi1)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:8645186, ECO:0000305|PubMed:8913348}.
scorpion