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Peptide record

TPDB27800

Neurotoxin Toxicity standard
35 amino acids
Basic Information
3D PDB MODEL
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TPDB27800
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 pep-lab Peptipedia ToxinPred 3.0
standard
No
A 35-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, pep-lab, Peptipedia, and other sources, with an available 3D structural model.
Sequence
GYCAEKGIRCDDIHCCTGLKCKCNASGYNCVCRKK
Physicochemical Analysis
C155H256N50O48S8
QMFPW
C
3844.52
8.31
8
3
8
+4
7.91
-0.409
47.43
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
3480
90.52
14
Residue Composition
number
2
A
2
R
2
N
2
D
8
C
1
E
0
Q
4
G
1
H
2
I
1
L
5
K
0
M
0
F
0
P
1
S
1
T
0
W
2
Y
1
V
Amino Acid Distribution
A: 2 R: 2 N: 2 D: 2 C: 8 E: 1 Q: 0 G: 4 H: 1 I: 2 L: 1 K: 5 M: 0 F: 0 P: 0 S: 1 T: 1 W: 0 Y: 2 V: 1
Chemical Descriptors
35
C155H256N50O48S8
3844.52
8.31
+4
7.91
-0.409
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Inhibits P2RX3 receptors. Has an analgesic effect in rat. Enhances the high-affinity desensitization of P2RX3 purinoceptors. At 50 nM, decreases the IC(50) for ambient ATP from 46.5 nM to 12.7 nM in mouse P2RX3. {ECO:0000269|PubMed:20437566, ECO:0000269|PubMed:22842000}.

Target

voltage-gated calcium channel (Cav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Alopecosa marikovskyi (Wolf spider) (Lycosa kazakhstanicus)
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin
Inhibits P2RX3 receptors. Has an analgesic effect in rat.
Purotoxin-1 (PT1) (OMICRON-lycotoxin-Am1a) (OMICRON-LCTX-Am1a)
spider
Neurotoxin 33 family
Evidence at protein level
3D-structure Calcium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:20437566}.
Additional Detail Fields 7 fields
3D-structure Calcium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin
Evidence at protein level
Neurotoxin 33 family
Purotoxin-1 (PT1) (OMICRON-lycotoxin-Am1a) (OMICRON-LCTX-Am1a)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:20437566}.
spider