Back to search

Peptide record

TPDB27798

Neurotoxin Toxicity standard
35 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB27798
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia pep-lab ToxinPred 3.0
standard
No
A 35-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, pep-lab, and other sources, with an available 3D structural model.
Sequence
GGCLPHNRFCNALSGPRCCSGLKCKELSIWDSRCL
Physicochemical Analysis
C160H259N51O46S6
QMTYV
C
3825.49
8.32
6
2
9
+3
3.22
-0.123
69.71
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
5875
153.58
12
Residue Composition
number
1
A
3
R
2
N
1
D
6
C
1
E
0
Q
4
G
1
H
1
I
5
L
2
K
0
M
1
F
2
P
4
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 3 N: 2 D: 1 C: 6 E: 1 Q: 0 G: 4 H: 1 I: 1 L: 5 K: 2 M: 0 F: 1 P: 2 S: 4 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
35
C160H259N51O46S6
3825.49
8.32
+3
3.22
-0.123
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Insect-selective toxin causing rapid but reversible paralysis in crickets. Suppresses the excitatory postsynaptic potentials evoked in lobster neuromuscular synaptic preparations, possibly by blocking the presynaptic calcium channel (Cav). Induces instantaneous reversible paralysis when injected into crickets. {ECO:0000269|PubMed:17644092}.

Target

voltage-gated calcium channel (Cav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Allagelena opulenta (Funnel weaving spider) (Agelena opulenta)
Neurotoxin Presynaptic neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Insect-selective toxin causing rapid but reversible paralysis in crickets. Suppresses the excitatory postsynaptic potentials evoked in lobster neuromuscular synaptic preparations, possibly by blocking the presynaptic calcium channel (Cav).
U2-agatoxin-Aop1a (U2-AGTX-Aop1a) (Agelenin)
spider
Neurotoxin 01 (U2-agtx) family
Evidence at protein level
3D-structure Amidation Calcium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Presynaptic neurotoxin Secreted Toxin Voltage-gated calcium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland.
Additional Detail Fields 7 fields
3D-structure Amidation Calcium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Presynaptic neurotoxin Secreted Toxin Voltage-gated calcium channel impairing toxin
Neurotoxin Presynaptic neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Evidence at protein level
Neurotoxin 01 (U2-agtx) family
U2-agatoxin-Aop1a (U2-AGTX-Aop1a) (Agelenin)
TISSUE SPECIFICITY: Expressed by the venom gland.
spider