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Peptide record

TPDB27788

Neurotoxin Toxicity standard
34 amino acids
Basic Information
3D PDB MODEL
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TPDB27788
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 pep-lab Peptipedia ToxinPred 3.0
standard
No
A 34-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, pep-lab, Peptipedia, and other sources, with an available 3D structural model.
Sequence
VSCTGSKDCYAPCRKQTGCPNAKCINKSCKCYGC
Physicochemical Analysis
C145H239N45O47S8
EHLMFW
C
3621.25
8.51
6
1
6
+5
5.63
-0.485
25.88
Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour
3480
96.10
18
Residue Composition
number
2
A
1
R
2
N
1
D
8
C
0
E
1
Q
3
G
0
H
1
I
0
L
5
K
0
M
0
F
2
P
3
S
2
T
0
W
2
Y
1
V
Amino Acid Distribution
A: 2 R: 1 N: 2 D: 1 C: 8 E: 0 Q: 1 G: 3 H: 0 I: 1 L: 0 K: 5 M: 0 F: 0 P: 2 S: 3 T: 2 W: 0 Y: 2 V: 1
Chemical Descriptors
34
C145H239N45O47S8
3621.25
8.51
+5
5.63
-0.485
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Blocks voltage-gated potassium channels Kv1.2/KCNA2 (IC(50)=0.12-0.8 nM), KCa3.1/KCNN4 (IC(50)=1-2.2 nM), Shaker B (IC(50)=2.39-80 nM), Kv1.1/KCNA1 (IC(50)=37-45 or no activity, depending on the study), Kv1.3/KCNA3 (IC(50)=150-180 or no activity, depending on the study). {ECO:0000269|PubMed:10888198, ECO:0000269|PubMed:10920011, ECO:0000269|PubMed:12527813, ECO:0000269|PubMed:15498765, ECO:0000269|PubMed:18042681, ECO:0000269|PubMed:9022673, ECO:0000269|PubMed:9136903}.

Target

voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Scorpio palmatus (Israeli golden scorpion) (Scorpio maurus palmatus)
Neurotoxin Calcium-activated potassium channel impairing toxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Blocks voltage-gated potassium channels Kv1.2/KCNA2 (IC(50)=0.12-0.8 nM), KCa3.1/KCNN4 (IC(50)=1-2.2 nM), Shaker B (IC(50)=2.39-80 nM), Kv1.1/KCNA1 (IC(50)=37-45 or no activity, depending on the study), Kv1.3/KCNA3 (IC(50)=150-180 or no activity, depending on the study)..
Potassium channel toxin alpha-KTx 6.2 (Maurotoxin) (MTX)
scorpion
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 06 subfamily
Evidence at protein level
3D-structure Amidation Calcium-activated potassium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:9022673}.
Additional Detail Fields 7 fields
3D-structure Amidation Calcium-activated potassium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
Neurotoxin Calcium-activated potassium channel impairing toxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Evidence at protein level
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 06 subfamily
Potassium channel toxin alpha-KTx 6.2 (Maurotoxin) (MTX)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:9022673}.
scorpion