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Peptide record

TPDB27786

Neurotoxin Toxicity standard
34 amino acids
Basic Information
3D PDB MODEL
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TPDB27786
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 pep-lab Peptipedia ToxinPred 3.0
standard
No
A 34-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, pep-lab, Peptipedia, and other sources, with an available 3D structural model.
Sequence
IRCSGSRDCYSPCMKQTGCPNAKCINKSCKCYGC
Physicochemical Analysis
C147H243N47O47S9
EHLFWV
C
3709.37
8.52
6
1
6
+5
5.00
-0.494
25.88
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
3480
93.82
18
Residue Composition
number
1
A
2
R
2
N
1
D
8
C
0
E
1
Q
3
G
0
H
2
I
0
L
4
K
1
M
0
F
2
P
4
S
1
T
0
W
2
Y
0
V
Amino Acid Distribution
A: 1 R: 2 N: 2 D: 1 C: 8 E: 0 Q: 1 G: 3 H: 0 I: 2 L: 0 K: 4 M: 1 F: 0 P: 2 S: 4 T: 1 W: 0 Y: 2 V: 0
Chemical Descriptors
34
C147H243N47O47S9
3709.37
8.52
+5
5.00
-0.494
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Antagonist of Kv1/KCNA potassium channels (Ref.1, Ref.2). Shows a weak interaction with muscle-type nicotinic acetylcholine receptors (nAChR), since it inhibits alpha-bungarotoxin binding to both muscle-type nAChR from T.californica (IC(50)=490 nM) (PubMed:31276191). This suggests it probably weakly inhibits nAChR (PubMed:31276191). {ECO:0000269|PubMed:31276191, ECO:0000269|Ref.1, ECO:0000269|Ref.2}.

Target

nicotinic acetylcholine receptor (nAChR) acetylcholine receptor voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Heterometrus spinifer (Asia giant forest scorpion) (Malaysian black scorpion)
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Antagonist of Kv1/KCNA potassium channels (Ref.1, Ref.2). Shows a weak interaction with muscle-type nicotinic acetylcholine receptors (nAChR), since it inhibits alpha-bungarotoxin binding to both muscle-type nAChR from T.californica (IC(50)=490 nM) (PubMed:31276191).
Potassium channel toxin alpha-KTx 6.13 (Spinoxin)
scorpion
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 06 subfamily
Evidence at protein level
Amidation Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
Additional Detail Fields 7 fields
Amidation Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Evidence at protein level
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 06 subfamily
Potassium channel toxin alpha-KTx 6.13 (Spinoxin)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
scorpion