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Peptide record

TPDB27781

Neurotoxin Toxicity standard
34 amino acids
Basic Information
3D PDB MODEL
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TPDB27781
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 pep-lab Peptipedia ToxinPred 3.0
standard
No
A 34-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, pep-lab, Peptipedia, and other sources, with an available 3D structural model.
Sequence
ASCRTPKDCADPCRKETGCPYGKCMNRKCKCNRC
Physicochemical Analysis
C149H253N53O47S9
QHILFWV
C
3827.52
8.74
9
3
4
+6
11.86
-1.135
5.88
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
1990
51.99
14
Residue Composition
number
2
A
4
R
2
N
2
D
8
C
1
E
0
Q
2
G
0
H
0
I
0
L
5
K
1
M
0
F
3
P
1
S
2
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 2 R: 4 N: 2 D: 2 C: 8 E: 1 Q: 0 G: 2 H: 0 I: 0 L: 0 K: 5 M: 1 F: 0 P: 3 S: 1 T: 2 W: 0 Y: 1 V: 0
Chemical Descriptors
34
C149H253N53O47S9
3827.52
8.74
+6
11.86
-1.135
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Potently blocks voltage-gated potassium channels Kv1.1/KCNA1 (IC(50)=7-11 nM) and Kv1.3/KCNA3 (IC(50)=11-29 pM) (PubMed:15498765, PubMed:24676092, PubMed:9359871). Also mildly blocks intermediate (IK) conductance calcium-activated potassium channels (KCa3.1/KCNN4) and ERG1/Kv11.1/KCNH2 (PubMed:15498765, PubMed:18687312). Shows ability to suppress proliferation of lymphocytes, which are known to be sensitive to Kv1.3/KCNA3 homotetrameric channel block (PubMed:24676092). {ECO:0000269|PubMed:15498765, ECO:0000269|PubMed:18687312, ECO:0000269|PubMed:24676092, ECO:0000269|PubMed:9359871}.

Target

voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Heterometrus spinifer (Asia giant forest scorpion) (Malaysian black scorpion)
Neurotoxin Calcium-activated potassium channel impairing toxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Potently blocks voltage-gated potassium channels Kv1.1/KCNA1 (IC(50)=7-11 nM) and Kv1.3/KCNA3 (IC(50)=11-29 pM) (PubMed:15498765, PubMed:24676092, PubMed:9359871). Also mildly blocks intermediate (IK) conductance calcium-activated potassium channels (KCa3.1/KCNN4) and ERG1/Kv11.1/KCNH2 (PubMed:15498765, PubMed:18687312).
Potassium channel toxin alpha-KTx 6.3 (Neurotoxin HsTX1)
scorpion
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 06 subfamily
Evidence at protein level
3D-structure Amidation Calcium-activated potassium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Pharmaceutical Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:9359871}.
Additional Detail Fields 7 fields
3D-structure Amidation Calcium-activated potassium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Pharmaceutical Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
Neurotoxin Calcium-activated potassium channel impairing toxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Evidence at protein level
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 06 subfamily
Potassium channel toxin alpha-KTx 6.3 (Neurotoxin HsTX1)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:9359871}.
scorpion