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Peptide record

TPDB27779

Neurotoxin Toxicity standard
34 amino acids
Basic Information
3D PDB MODEL
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TPDB27779
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 pep-lab Peptipedia ToxinPred 3.0
standard
No
A 34-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, pep-lab, Peptipedia, and other sources, with an available 3D structural model.
Sequence
ACSGRGSRCPPQCCMGLRCGRGNPQKCIGAHEDV
Physicochemical Analysis
C138H232N52O44S7
FTWY
CG
3548.10
8.32
6
2
6
+3
8.88
-0.541
37.35
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
375
10.57
11
Residue Composition
number
2
A
4
R
1
N
1
D
6
C
1
E
2
Q
6
G
1
H
1
I
1
L
1
K
1
M
0
F
3
P
2
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 2 R: 4 N: 1 D: 1 C: 6 E: 1 Q: 2 G: 6 H: 1 I: 1 L: 1 K: 1 M: 1 F: 0 P: 3 S: 2 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
34
C138H232N52O44S7
3548.10
8.32
+3
8.88
-0.541
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Mu-conotoxins block voltage-gated sodium channels (Nav). No effect was observed upon injections into mice and goldfish (25 ug). {ECO:0000269|PubMed:2851318}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus geographus (Geography cone) (Nubecula geographus)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Mu-conotoxins block voltage-gated sodium channels (Nav). No effect was observed upon injections into mice and goldfish (25 ug)..
Mu-conotoxin GS (CGS)
cone snail
Evidence at protein level
3D-structure Direct protein sequencing Disulfide bond Gamma-carboxyglutamic acid Hydroxylation Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom duct.
Additional Detail Fields 6 fields
3D-structure Direct protein sequencing Disulfide bond Gamma-carboxyglutamic acid Hydroxylation Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Mu-conotoxin GS (CGS)
TISSUE SPECIFICITY: Expressed by the venom duct.
cone snail