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Peptide record

TPDB27773

Neurotoxin Toxicity standard
33 amino acids
Basic Information
3D PDB MODEL
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TPDB27773
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia pep-lab ToxinPred 3.0
standard
No
A 33-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, pep-lab, and other sources, with an available 3D structural model.
Sequence
DCLKFGWKCNPRNDKCCSGLKCGSNHNWCKLHI
Physicochemical Analysis
C162H251N51O44S6
AEQMTYV
C
3809.45
8.59
8
2
7
+4
4.30
-0.724
47.27
Mammalian: 1.1 hour Yeast: 3 min E.coli: >10 hour
11375
298.60
12
Residue Composition
number
0
A
1
R
4
N
2
D
6
C
0
E
0
Q
3
G
2
H
1
I
3
L
5
K
0
M
1
F
1
P
2
S
0
T
2
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 1 N: 4 D: 2 C: 6 E: 0 Q: 0 G: 3 H: 2 I: 1 L: 3 K: 5 M: 0 F: 1 P: 1 S: 2 T: 0 W: 2 Y: 0 V: 0
Chemical Descriptors
33
C162H251N51O44S6
3809.45
8.59
+4
4.30
-0.724
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Inhibits voltage-gated sodium channels without significantly altering the voltage dependence of activation or inactivation. Preferentially inhibits human Nav1.7/SCN9A (IC(50)=2.1 nM) > human Nav1.6/SCN8A > human Nav1.2/SCN2A > human Nav1.1/SCN1A > human Nav1.3/SCN3A channels. Exhibits analgesic properties by reversing spontaneous pain induced in mice by intraplantar injection with OD1 (AC P84646), a scorpion toxin that potentiates human Nav1.7/SCN9A. {ECO:0000269|PubMed:25979003}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Thrixopelma pruriens (Peruvian green velvet tarantula)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Inhibits voltage-gated sodium channels without significantly altering the voltage dependence of activation or inactivation. Preferentially inhibits human Nav1.7/SCN9A (IC(50)=2.1 nM) > human Nav1.6/SCN8A > human Nav1.2/SCN2A > human Nav1.1/SCN1A > human Nav1.3/SCN3A channels.
Mu-theraphotoxin-Tp1a (Mu-TRTX-Tp1a) (Protoxin III) (ProTx-III)
spider
Neurotoxin 10 (Hwtx-1) family, 55 (ProTx-III) subfamily
Evidence at protein level
3D-structure Amidation Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:25979003}.
Additional Detail Fields 7 fields
3D-structure Amidation Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Neurotoxin 10 (Hwtx-1) family, 55 (ProTx-III) subfamily
Mu-theraphotoxin-Tp1a (Mu-TRTX-Tp1a) (Protoxin III) (ProTx-III)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:25979003}.
spider