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Peptide record

TPDB27768

Neurotoxin Toxicity standard
32 amino acids
Basic Information
3D PDB MODEL
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TPDB27768
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 pep-lab Peptipedia ToxinPred 3.0
standard
No
A 32-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, pep-lab, Peptipedia, and other sources, with an available 3D structural model.
Sequence
VGCAECPMHCKGKMAKPTCENEVCKCNIGKKD
Physicochemical Analysis
C139H236N42O44S8
RQLFSWY
CK
3456.14
8.02
7
4
7
+2
13.69
-0.544
36.56
Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour
375
10.85
9
Residue Composition
number
2
A
0
R
2
N
1
D
6
C
3
E
0
Q
3
G
1
H
1
I
0
L
6
K
2
M
0
F
2
P
0
S
1
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 2 R: 0 N: 2 D: 1 C: 6 E: 3 Q: 0 G: 3 H: 1 I: 1 L: 0 K: 6 M: 2 F: 0 P: 2 S: 0 T: 1 W: 0 Y: 0 V: 2
Chemical Descriptors
32
C139H236N42O44S8
3456.14
8.02
+2
13.69
-0.544
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Blocker of human voltage-gated potassium channel Kv1.1/KCNA1 (PubMed:12650917). {ECO:0000269|PubMed:12650917}.

Target

voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Hottentotta tamulus (Eastern Indian scorpion) (Mesobuthus tamulus)
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Blocker of human voltage-gated potassium channel Kv1.1/KCNA1 (PubMed:12650917)..
Potassium channel toxin alpha-KTx 9.4 (BTK-2)
scorpion
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 09 subfamily
Evidence at protein level
3D-structure Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:12650917}.
Additional Detail Fields 7 fields
3D-structure Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Evidence at protein level
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 09 subfamily
Potassium channel toxin alpha-KTx 9.4 (BTK-2)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:12650917}.
scorpion