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Peptide record

TPDB27764

Neurotoxin Toxicity standard
32 amino acids
Basic Information
3D PDB MODEL
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TPDB27764
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 pep-lab Peptipedia ToxinPred 3.0
standard
No
A 32-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, pep-lab, Peptipedia, and other sources, with an available 3D structural model.
Sequence
DDCIKPYGFCSLPILKNGLCCSGACVGVCADL
Physicochemical Analysis
C140H225N35O43S6
REQHMTW
C
3278.90
4.17
2
3
12
-1
0.72
0.766
97.50
Mammalian: 1.1 hour Yeast: 3 min E.coli: >10 hour
1865
56.88
10
Residue Composition
number
2
A
0
R
1
N
3
D
6
C
0
E
0
Q
4
G
0
H
2
I
4
L
2
K
0
M
1
F
2
P
2
S
0
T
0
W
1
Y
2
V
Amino Acid Distribution
A: 2 R: 0 N: 1 D: 3 C: 6 E: 0 Q: 0 G: 4 H: 0 I: 2 L: 4 K: 2 M: 0 F: 1 P: 2 S: 2 T: 0 W: 0 Y: 1 V: 2
Chemical Descriptors
32
C140H225N35O43S6
3278.90
4.17
-1
0.72
0.766
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Delta-conotoxins bind to site 6 of voltage-gated sodium channels and inhibit the inactivation process. This toxin inhibits sodium channel inactivation in neuronal membranes from amphibians and mammals (Nav1.2a/SCN1A, Nav1.3/SCN3A and Nav1.6/SCN8A) upon binding to receptor site 6. {ECO:0000269|PubMed:14615484}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus ermineus (Agate cone) (Chelyconus ermineus)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Delta-conotoxins bind to site 6 of voltage-gated sodium channels and inhibit the inactivation process. This toxin inhibits sodium channel inactivation in neuronal membranes from amphibians and mammals (Nav1.2a/SCN1A, Nav1.3/SCN3A and Nav1.6/SCN8A) upon binding to receptor site 6..
Delta-conotoxin EVIA (Delta-EVIA)
cone snail
Conotoxin O1 superfamily
Evidence at protein level
3D-structure Amidation Direct protein sequencing Disulfide bond Hydroxylation Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000269|PubMed:14615484, ECO:0000269|PubMed:14976206}.
Additional Detail Fields 7 fields
3D-structure Amidation Direct protein sequencing Disulfide bond Hydroxylation Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Conotoxin O1 superfamily
Delta-conotoxin EVIA (Delta-EVIA)
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000269|PubMed:14615484, ECO:0000269|PubMed:14976206}.
cone snail